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TEC-/- BTK-/- double mutant T cells exhibit severely impaired T cell activitity. RLK-/-ITK-/- double mutant celles exhibit severely imparired Th2 responses. Grb2(+/-) mice disrupt T cell signaling networks and development. Dendric cells and macrophages of MEK3 deficient mice have impaired IL12 production. Bam32(-/-) B cell develop normally but have impaired T-independent antibody responses in vivo. T-cell and B-cell of RAP1A deficient mice impair integrin-mediated cell adhesion. T-cell of WASP deficient mice impair the proliferaction and antigen receptor cap formation in response to anti-CD3zeta stimulation. T-cell of SHB defective mice impair the phosphorylation of LAT and consequently the activation of MAP kinase pathways. B-cell of 3BP2 (-/-) deficient mice have defective in proliferation, cell cycle progression, PLC-gamma2 phosphorylation, calcium mobilization, NF-ATp dephosphorylation, and Erk and Jnk activation in response to BCR ligation. B-cell of Vav2(-/-) deficient mice are defective in the ability to switch immunoglobulin class. T-cell of Vav1(-/-) deficient mice exhibit impaired antigen receptor signaling. Vav1(-/-)Vav2(-/-) mice exhibit greatly reduced the mature B-cells. Vav-1-/-Vav-2-/- B cells were unresponsive to BCR-driven proliferation in vitro and to thymus-indepen-dent antigen in vivo. Fyn-deficient mice exhibit a remarkably specific lymphoid defect thymocytes are refractile to stimulation through the TCR with mitogen or antigen. Lck-deficient mice show a pronounced thymic atrophy, with a dramatic reduction in the double-positive (CD4+CD8+) thymocyte population. T cell from mice deficient in LCK is required for normal signal transduction through the TCR. T cells from mice deficient in SLAP-130/Fyb show markedly impaired proliferation. B cell of chicken deficient ITK reduce IP3 generation and phospholipase C gamma 2 tyrosine phosphorylation. T cell of mice deficient ITK reduce IP3 generation and phospholipase C gamma 1 tyrosine phosphorylation. T cell of mice deficient ITK have failure of Th2 development. Mice deficient in ITK have reduced proliferative responses to MHC stimulation and to anti-TCR cross-linking Mutations in Btk cause X-linked immunodeficiency. Gads(GRAP2) has a role in thymocyte proliferaction for maturation of T-cells. Gads(GRAP2) has a role for homeostatic proliferaction in B cells. Grap negatively regulates T-cell proliferation. Gab2 is a substrate of ZAP-70 and functions as a switch molecule toward inhibition of TCR signal transuduction. B cell signaling causes tyrosine phosphorylation of Gab1, and in turn SHP2 bind to Gab1 Gab1 phosophorylation potentiate the phosphorylation of Akt, PI3K-dependent response. RasGRP1 mediates Ras activation following TCR stimulatioin. RasGRP1 and RasGRP3 induces RAS activation in B-cell to response to T-cell stimulation. Grb2-hSos1-PLCgamma1-p36/p38-ZAP70 complexes localize in the vicinity of TCR-zeta Gads(Grap2) plays an important role in T-cell signaling via its association with SLP-76 and LAT. Lck is required for normal signal transduction through the TCR. ZAP-70 plays crucial roles in T-cell activation and development. Syk triggers cellular activation in T-cell. TEC-/- BTK-/- double mutant T cells exhibit severely impaired T cell activitity. 1 J Exp Med. 2000 Dec 4;192(11) 1611-24. Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk. Ellmeier W, Jung S, Sunshine MJ, Hatam F, Xu Y, Baltimore D, Mano H, Littman DR. Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine. wilfried.ellmeier@univie.ac.at The cytoplasmic protein tyrosine kinase Tec has been proposed to have important functions in hematopoiesis and lymphocyte signal transduction. Here we show that Tec-deficient mice developed normally and had no major phenotypic alterations of the immune system. To reveal potential compensatory roles of other Tec kinases such as Bruton s tyrosine kinase (Btk), Tec/Btk double-deficient mice were generated. These mice exhibited a block at the B220(+)CD43(+) stage of B cell development and displayed a severe reduction of peripheral B cell numbers, particularly immunoglobulin (Ig)M(lo)IgD(hi) B cells. Although Tec/Btk(null) mice were able to form germinal centers, the response to T cell-dependent antigens was impaired. Thus, Tec and Btk together have an important role both during B cell development and in the generation and/or function of the peripheral B cell pool. The ability of Tec to compensate for Btk may also explain phenotypic differences in X-linked immunodeficiency (xid) mice compared with human X-linked agammaglobulinemia (XLA) patients. Publication Types Research Support, Non-U.S. Gov t PMID 11104803 [PubMed - indexed for MEDLINE] RLK-/-ITK-/- double mutant celles exhibit severely imparired Th2 responses. 1 Nat Immunol. 2001 Dec;2(12) 1183-8. Mutation of Tec family kinases alters T helper cell differentiation. Schaeffer EM, Yap GS, Lewis CM, Czar MJ, McVicar DW, Cheever AW, Sher A, Schwartzberg PL. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. The Tec kinases Rlk and Itk are critical for full T cell receptor (TCR)-induced activation of phospholipase C-gamma and mitogen-activated protein kinase. We show here that the mutation of Rlk and Itk impaired activation of the transcription factors NFAT and AP-1 and production of both T helper type 1 (TH1) and TH2 cytokines. Consistent with these biochemical defects, Itk-/- mice did not generate effective TH2 responses when challenged with Schistosoma mansoni eggs. Paradoxically, the more severely impaired Rlk-/-Itk-/- mice were able to mount a TH2 response and produced TH2 cytokines in response to this challenge. In addition, Rlk-/-Itk-/- cells showed impaired TCR-induced repression of the TH2-inducing transcription factor GATA-3, suggesting a potential mechanism for TH2 development in these hyporesponsive cells. Thus, mutations that affect Tec kinases lead to complex alterations in CD4+ TH cell differentiation. Publication Types Research Support, Non-U.S. Gov t Research Support, U.S. Gov t, P.H.S. PMID 11702066 [PubMed - indexed for MEDLINE] Grb2(+/-) mice disrupt T cell signaling networks and development. 1 Nat Immunol. 2001 Jan;2(1) 29-36. Disruption of T cell signaling networks and development by Grb2 haploid insufficiency. Gong Q, Cheng AM, Akk AM, Alberola-Ila J, Gong G, Pawson T, Chan AC. Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110, USA. The developmental processes of positive and negative selection in the thymus shape the T cell antigen receptor (TCR) repertoire and require the integration of multiple signaling networks. These networks involve the efficient assembly of macromolecular complexes and are mediated by multimodular adaptor proteins that permit the functional integration of distinct signaling molecules. We show here that decreased expression of the adaptor protein Grb2 in Grb2+/- mice weakens TCR-induced c-Jun N-terminal kinase (JNK) and p38, but not extracellular signal-regulated kinase (ERK), activation. In turn, this selective effect decreases the ability of thymocytes to undergo negative, but not positive, selection. We also show that there are differences in the signaling thresholds of the three mitogen-activated protein kinase (MAPK) families. These differences may provide a mechanism by which quantitative differences in signal strength can alter the balance of downstream signaling pathways to induce the qualitatively distinct biological outcomes of proliferation, differentiation or apoptosis. PMID 11135575 [PubMed - indexed for MEDLINE] Dendric cells and macrophages of MEK3 deficient mice have impaired IL12 production. 1 EMBO J. 1999 Apr 1;18(7) 1845-57. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. Lu HT, Yang DD, Wysk M, Gatti E, Mellman I, Davis RJ, Flavell RA. Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA. The p38 mitogen-activated protein kinase (MAPK) pathway, like the c-Jun N-terminal kinase (JNK) MAPK pathway, is activated in response to cellular stress and inflammation and is involved in many fundamental biological processes. To study the role of the p38 MAPK pathway in vivo, we have used homologous recombination in mice to inactivate the Mkk3 gene, one of the two specific MAPK kinases (MAPKKs) that activate p38 MAPK. Mkk3(-/-) mice were viable and fertile; however, they were defective in interleukin-12 (IL-12) production by macrophages and dendritic cells. Interferon-gamma production following immunization with protein antigens and in vitro differentiation of naive T cells is greatly reduced, suggesting an impaired type I cytokine immune response. The effect of the p38 MAPK pathway on IL-12 expression is at least partly transcriptional, since inhibition of this pathway blocks IL-12 p40 promoter activity in macrophage cell lines and IL-12 p40 mRNA is reduced in MKK3-deficient mice. We conclude that the p38 MAP kinase, activated through MKK3, is required for the production of inflammatory cytokines by both antigen-presenting cells and CD4(+) T cells. PMID 10202148 [PubMed - indexed for MEDLINE] Bam32(-/-) B cell develop normally but have impaired T-independent antibody responses in vivo. 1 Immunity. 2003 Oct;19(4) 621-32. Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival. Han A, Saijo K, Mecklenbrauker I, Tarakhovsky A, Nussenzweig MC. Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10021, USA. Bam32 is an adaptor protein recruited to the plasma membrane upon B cell receptor (BCR) crosslinking in a phosphoinositol 3-kinase (PI3K)-dependent manner; however, its physiologic function is unclear. To determine its physiologic function, we produced Bam32-deficient mice. Bam32(-/-) B cells develop normally but have impaired T-independent antibody responses in vivo and diminished responses to BCR crosslinking in vitro. Biochemical analysis revealed that Bam32 acts in a novel pathway leading from the BCR to MAPK/ERK Kinases (MEK1/2), MAPK/ERK Kinase Kinase-1 (MEKK1), extracellular signal-regulated kinase (ERK), and c-jun NH2-terminal kinase (JNK), but not p38 mitogen-activated protein kinase (p38). This pathway appears to be initiated by hematopoietic progenitor kinase-1 (HPK1), which interacts directly with Bam32, and differs from all previously characterized BCR signaling pathways in that it is required for normal BCR-mediated proliferation but not for B cell survival. PMID 14563325 [PubMed - indexed for MEDLINE] T-cell and B-cell of RAP1A deficient mice impair integrin-mediated cell adhesion. 1 Mol Cell Biol. 2006 Jan;26(2) 643-53. Rap1A-deficient T and B cells show impaired integrin-mediated cell adhesion. Duchniewicz M, Zemojtel T, Kolanczyk M, Grossmann S, Scheele JS, Zwartkruis FJ. Department of Computational Molecular Biology, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, D-14195 Berlin, Germany. Studies in tissue culture cells have demonstrated a role for the Ras-like GTPase Rap1 in the regulation of integrin-mediated cell-matrix and cadherin-mediated cell-cell contacts. To analyze the function of Rap1 in vivo, we have disrupted the Rap1A gene by homologous recombination. Mice homozygous for the deletion allele are viable and fertile. However, primary hematopoietic cells isolated from spleen or thymus have a diminished adhesive capacity on ICAM and fibronectin substrates. In addition, polarization of T cells from Rap1-/- cells after CD3 stimulation was impaired compared to that of wild-type cells. Despite this, these defects did not result in hematopoietic or cell homing abnormalities. Although it is possible that the relatively mild phenotype is a consequence of functional complementation by the Rap1B gene, our genetic studies confirm a role for Rap1A in the regulation of integrins. PMID 16382154 [PubMed - indexed for MEDLINE] T-cell of WASP deficient mice impair the proliferaction and antigen receptor cap formation in response to anti-CD3zeta stimulation. 1 Immunity. 1998 Jul;9(1) 81-91. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Snapper SB, Rosen FS, Mizoguchi E, Cohen P, Khan W, Liu CH, Hagemann TL, Kwan SP, Ferrini R, Davidson L, Bhan AK, Alt FW. Howard Hughes Medical Institute, Children s Hospital, Boston, Massachusetts 02115, USA. The Wiskott-Aldrich syndrome (WAS) is a human X-linked immunodeficiency resulting from mutations in a gene (WASP) encoding a cytoplasmic protein implicated in regulating the actin cytoskeleton. To elucidate WASP function, we disrupted the WASP gene in mice by gene-targeted mutation. WASP-deficient mice showed apparently normal lymphocyte development, normal serum immunoglobulin levels, and the capacity to respond to both T-dependent and T-independent type II antigens. However, these mice did have decreased peripheral blood lymphocyte and platelet numbers and developed chronic colitis. Moreover, purified WASP-deficient T cells showed markedly impaired proliferation and antigen receptor cap formation in response to anti-CD3epsilon stimulation. Yet, purified WASP-deficient B cells showed normal responses to anti-Ig stimulation. We discuss the implications of our findings regarding WASP function in receptor signaling and cytoskeletal reorganization in T and B cells and compare the effects of WASP deficiency in mice and humans. PMID 9697838 [PubMed - indexed for MEDLINE] T-cell of SHB defective mice impair the phosphorylation of LAT and consequently the activation of MAP kinase pathways. 9 Sep 24;274(39) 28050-7. Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells. Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M. Department of Medical Cell Biology, Box 571, Biomedicum, Uppsala University, S-75123 Uppsala, Sweden. Stimulation of the T cell antigen receptor (TCR) induces tyrosine phosphorylation of numerous intracellular proteins. We have recently investigated the role of the adaptor protein Shb in the early events of T cell signaling and observed that Shb associates with Grb2, linker for activation of T cells (LAT) and the TCR zeta-chain in Jurkat cells. We now report that Shb also associates with phospholipase C-gamma1 (PLC-gamma1) in these cells. Overexpression of Src homology 2 domain defective Shb caused diminished phosphorylation of LAT and consequently the activation of mitogen-activated protein kinases was decreased upon TCR stimulation. In addition, the Shb mutant also blocked phosphorylation of PLC-gamma1 and the increase in cytoplasmic Ca(2+) following TCR stimulation. Nuclear factor for activation of T cells is a major target for Ras and calcium signaling pathways in T cells following TCR stimulation, and the overexpression of the mutant Shb prevented TCR-dependent activation of the nuclear factor for activation of T cells. Consequently, endogenous interleukin-2 production was decreased under these conditions. The results indicate a role for Shb as a link between the TCR and downstream signaling events involving LAT and PLC-gamma1 and resulting in the activation of transcription of the interleukin-2 gene. PMID 10488157 [PubMed - indexed for MEDLINE] B-cell of 3BP2 (-/-) deficient mice have defective in proliferation, cell cycle progression, PLC-gamma2 phosphorylation, calcium mobilization, NF-ATp dephosphorylation, and Erk and Jnk activation in response to BCR ligation. 1 Mol Cell Biol. 2006 Jul;26(14) 5214-25. 3BP2 deficiency impairs the response of B cells, but not T cells, to antigen receptor ligation. de la Fuente MA, Kumar L, Lu B, Geha RS. Division of Immunology, Children s Hospital, 300 Longwood Ave., Boston, MA 02115, USA. The adapter protein 3BP2 is expressed in lymphocytes; binds to Syk/ZAP-70, Vav, and phospholipase C-gamma (PLC-gamma); and is thought to be important for interleukin-2 gene transcription in T cells. To define the role of 3BP2 in lymphocyte development and function, we generated 3BP2-deficient mice. T-cell development, proliferation, cytokine secretion, and signaling in response to T-cell receptor (TCR) ligation were all normal in 3BP2(-/-) mice. 3BP2(-/-) mice had increased accumulation of pre-B cells in the bone marrow and a block in the progression of transitional B cells in the spleen from the T1 to the T2 stage, but normal numbers of mature B cells. B-cell proliferation, cell cycle progression, PLC-gamma2 phosphorylation, calcium mobilization, NF-ATp dephosphorylation, and Erk and Jnk activation in response to B-cell receptor (BCR) ligation were all impaired. These results suggest that 3BP2 is important for BCR, but not for TCR signaling. PMID 16809760 [PubMed - indexed for MEDLINE] B-cell of Vav2(-/-) deficient mice are defective in the ability to switch immunoglobulin class. 1 Nat Immunol. 2001 Jun;2(6) 542-7. Comment in Nat Immunol. 2001 Jun;2(6) 482-4. Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation. Doody GM, Bell SE, Vigorito E, Clayton E, McAdam S, Tooze R, Fernandez C, Lee IJ, Turner M. Laboratory of Lymphocyte Signaling and Development, Molecular Immunology Programme, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK. B and T lymphocytes develop normally in mice lacking the guanine nucleotide exchange factor Vav-2. However, the immune responses to type II thymus-independent antigen as well as the primary response to thymus-dependent (TD) antigen are defective. Vav-2-deficient mice are also defective in their ability to switch immunoglobulin class, form germinal centers and generate secondary immune responses to TD antigens. Mice lacking both Vav-1 and Vav-2 contain reduced numbers of B lymphocytes and display a maturational block in the development of mature B cells. B cells from Vav-1(-/-)Vav-2(-/-) mice respond poorly to antigen receptor triggering, both in terms of proliferation and calcium release. These studies show the importance of Vav-2 in humoral immune responses and B cell maturation. PMID 11376342 [PubMed - indexed for MEDLINE] T-cell of Vav1(-/-) deficient mice exhibit impaired antigen receptor signaling. 1 Nature. 1995 Mar 30;374(6521) 474-7. Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes. Fischer KD, Zmuldzinas A, Gardner S, Barbacid M, Bernstein A, Guidos C. Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. During lymphocyte development, cellular proliferation and positive and negative selection events ensure the production of T and B lymphocytes bearing highly diverse, but self-tolerant, repertoires of antigen receptors. These processes are initiated when engagement of growth-factor receptors, or the T and B lymphocyte antigen receptors, induces tyrosine phosphorylation of specific SH2- and SH3-domain-containing cytoplasmic proteins, including Vav. Here we show that vav-/- embryonic stem cells generate only limited numbers of immature and mature T and B lymphocytes in the RAG-2 blastocyst complementation assay. Furthermore, Vav-deficient T lymphocytes showed severely impaired antigen receptor signalling. Finally, we demonstrate that Vav-dependent signalling pathways regulate maturation, but not CD4/CD8 lineage commitment, during T-cell-receptor-mediated positive selection of immature CD4+ CD8+ precursors into mature CD4+ CD8- or CD4- CD8+ T cells. PMID 7700360 [PubMed - indexed for MEDLINE] Vav1(-/-)Vav2(-/-) mice exhibit greatly reduced the mature B-cells. Vav-1-/-Vav-2-/- B cells were unresponsive to BCR-driven proliferation in vitro and to thymus-indepen-dent antigen in vivo. 1 Nat Immunol. 2001 Jun;2(6) 548-55. Comment in Nat Immunol. 2001 Jun;2(6) 482-4. Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling. Tedford K, Nitschke L, Girkontaite I, Charlesworth A, Chan G, Sakk V, Barbacid M, Fischer KD. Abteilung Physiologische Chemie, Universitat Ulm, Albert-Einstein-Allee 11, D-89069 Ulm, Germany. Vav-1 and Vav-2 are closely related Dbl-homology GTP exchange factors (GEFs) for Rho GTPases. Mutation of Vav-1 disrupts T cell development and T cell antigen receptor-induced activation, but has comparatively little effect on B cells. We found that combined deletion of both Vav-1 and Vav-2 in mice resulted in a marked reduction in mature B lymphocyte numbers. Vav-1(-/-)Vav-2(-/-) B cells were unresponsive to B cell antigen receptor (BCR)-driven proliferation in vitro and to thymus-independent antigen in vivo. BCR-stimulated intracellular calcium mobilization was greatly impaired in Vav-1(-/-)Vav-2(-/-) B cells. These findings establish a role for Vav-2 in BCR calcium signaling and reveal that the Vav family of GEFs is critical to B cell development and function. PMID 11376343 [PubMed - indexed for MEDLINE] Fyn-deficient mice exhibit a remarkably specific lymphoid defect thymocytes are refractile to stimulation through the TCR with mitogen or antigen. 1 Cell. 1992 Sep 4;70(5) 751-63. Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn. Appleby MW, Gross JA, Cooke MP, Levin SD, Qian X, Perlmutter RM. Howard Hughes Medical Institute, Department of Immunology, University of Washington, Seattle 98195. Considerable evidence supports the hypothesis that the nonreceptor protein tyrosine kinase p59fyn participates in signal transduction from the T cell receptor (TCR). To examine this hypothesis in detail, we have produced mice that lack the thymic isoform of p59fyn but retain expression of the brain isoform of the protein. fynTnull mice exhibit a remarkably specific lymphoid defect thymocytes are refractile to stimulation through the TCR with mitogen or antigen, while peripheral T cells, following what appears to be a normal maturation sequence, reacquire significant signaling capabilities. These data confirm that p59fynT plays a pivotal role in TCR signal transduction and demonstrate that additional developmentally regulated signaling components also contribute to TCR-induced lymphocyte activation. PMID 1516132 [PubMed - indexed for MEDLINE] Lck-deficient mice show a pronounced thymic atrophy, with a dramatic reduction in the double-positive (CD4+CD8+) thymocyte population. 1 Nature. 1992 May 14;357(6374) 161-4. Comment in Nature. 1993 Jan 21;361(6409) 213. Profound block in thymocyte development in mice lacking p56lck. Molina TJ, Kishihara K, Siderovski DP, van Ewijk W, Narendran A, Timms E, Wakeham A, Paige CJ, Hartmann KU, Veillette A, et al. Ontario Cancer Institute, University of Toronto, Canada. The protein Lck (p56lck) has a relative molecular mass of 56,000 and belongs to the Src family of tyrosine kinases. It is expressed exclusively in lymphoid cells, predominantly in thymocytes and peripheral T cells. Lck associates specifically with the cytoplasmic domains of both CD4 and CD8 T-cell surface glycoproteins and interacts with the beta-chain of the interleukin-2 receptor, which implicates Lck activity in signal transduction during thymocyte ontogeny and activation of mature T cells. Here we generate an lck null mutation by homologous recombination in embryonic stem cells to evaluate the role of p56lck in T-cell development and activation. Lck-deficient mice show a pronounced thymic atrophy, with a dramatic reduction in the double-positive (CD4+CD8+) thymocyte population. Mature, single-positive thymocytes are not detectable in these mice and there are only very few peripheral T cells. These results illustrate the crucial role of this T-cell-specific tyrosine kinase in the thymocyte development. PMID 1579166 [PubMed - indexed for MEDLINE] T cell from mice deficient in LCK is required for normal signal transduction through the TCR. 1 Cell. 1992 Aug 21;70(4) 585-93. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Straus DB, Weiss A. Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco 94143. Signaling through the T cell antigen receptor (TCR) results both in rapid increases in tyrosine phosphorylation on a number of proteins and in the activation of the phosphatidylinositol pathway. It is not clear how stimulation of the TCR leads to these signaling events. Mutants of the Jurkat T cell line have been previously isolated that fail to show increases in calcium following receptor stimulation. Analysis of one of these mutants, JCaM1, which is defective in the induction of tyrosine phosphorylation, revealed a defect in the expression of functional lck tyrosine kinase. The lack of lck activity was caused in part by a splicing defect. Expression of the lck cDNA in JCaM1 restores the ability of the cell to respond to TCR stimulation. These results indicate that lck is required for normal signal transduction through the TCR. PMID 1505025 [PubMed - indexed for MEDLINE] T cells from mice deficient in SLAP-130/Fyb show markedly impaired proliferation. 1 Science. 2001 Sep 21;293(5538) 2263-5. Coupling of the TCR to integrin activation by Slap-130/Fyb. Peterson EJ, Woods ML, Dmowski SA, Derimanov G, Jordan MS, Wu JN, Myung PS, Liu QH, Pribila JT, Freedman BD, Shimizu Y, Koretzky GA. The Abramson Family Cancer Research Institute, Department of Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. SLAP-130/Fyb (SLP-76-associated phosphoprotein or Fyn-binding protein; also known as Fyb/Slap) is a hematopoietic-specific adapter, which associates with and modulates function of SH2-containing leukocyte phosphoprotein of 76 kilodaltons (SLP-76). T cells from mice lacking SLAP-130/Fyb show markedly impaired proliferation following CD3 engagement. In addition, the T cell receptor (TCR) in SLAP-130/Fyb mutant cells fails to enhance integrin-dependent adhesion. Although TCR-induced actin polymerization is normal, TCR-stimulated clustering of the integrin LFA-1 is defective in SLAP-130/Fyb-deficient cells. These data indicate that SLAP-130/Fyb is important for coupling TCR-mediated actin cytoskeletal rearrangement with activation of integrin function, and for T cells to respond fully to activating signals. PMID 11567141 [PubMed - indexed for MEDLINE] B cell of chicken deficient ITK reduce IP3 generation and phospholipase C gamma 2 tyrosine phosphorylation. 1 J Exp Med. 1996 Jul 1;184(1) 31-40. A role for Bruton s tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2. Takata M, Kurosaki T. Department of Oncology and Immunology, Wyeth-Ayerst Research, Pearl River, New York 10965, USA. Defects in the gene encoding Bruton s tyrosine kinase (Btk) result in a disease called X-linked agammaglobulinemia, in which there is a profound decrease of mature B cells due to a block in B cell development. Recent studies have shown that Btk is tyrosine phosphorylated and activated upon B cell antigen receptor (BCR) stimulation. To elucidate the functions of this kinase, we examined BCR signaling of DT40 B cells deficient in Btk. Tyrosine phosphorylation of phospholipase C (PLC)-gamma 2 upon receptor stimulation was significantly reduced in the mutant cells, leading to the loss of both BCR-coupled phosphatidylinositol hydrolysis and calcium mobilization. Pleckstrin homology and Src-homology 2 domains of Btk were required for PLC-gamma 2 activation. Since Syk is also required for the BCR-induced PLC-gamma 2 activation, our findings indicate that PLC-gamma 2 activation is regulated by Btk and Syk through their concerted actions. PMID 8691147 [PubMed - indexed for MEDLINE] T cell of mice deficient ITK reduce IP3 generation and phospholipase C gamma 1 tyrosine phosphorylation. 1 J Exp Med. 1998 May 18;187(10) 1721-7. T cell receptor-initiated calcium release is uncoupled from capacitative calcium entry in Itk-deficient T cells. Liu KQ, Bunnell SC, Gurniak CB, Berg LJ. Program of Immunology, Division of Medical Sciences, Harvard University, Boston, Massachusetts 02115, USA. Itk, a Tec family tyrosine kinase, plays an important but as yet undefined role in T cell receptor (TCR) signaling. Here we show that T cells from Itk-deficient mice have a TCR-proximal signaling defect, resulting in defective interleukin 2 secretion. Upon TCR stimulation, Itk-/- T cells release normal amounts of calcium from intracellular stores, but fail to open plasma membrane calcium channels. Since thapsigargin-induced store depletion triggers normal calcium entry in Itk-/- T cells, an impaired biochemical link between store depletion and channel opening is unlikely to be responsible for this defect. Biochemical studies indicate that TCR-induced inositol 1,4,5 tris-phosphate (IP3) generation and phospholipase C gamma1 tyrosine phosphorylation are substantially reduced in Itk-/- T cells. In contrast, TCR-zeta and ZAP-70 are phosphorylated normally, suggesting that Itk functions downstream of, or in parallel to, ZAP-70 to facilitate TCR-induced IP3 production. These findings support a model in which quantitative differences in cytosolic IP3 trigger distinct responses, and in which only high concentrations of IP3 trigger the influx of extracellular calcium. PMID 9584150 [PubMed - indexed for MEDLINE] T cell of mice deficient ITK have failure of Th2 development. 1 Immunity. 1999 Oct;11(4) 399-409. Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells. Fowell DJ, Shinkai K, Liao XC, Beebe AM, Coffman RL, Littman DR, Locksley RM. Department of Medicine, University of California San Francisco 94143, USA. Naive Itk-deficient CD4+ T cells were unable to establish stable IL-4 production, even when primed in Th2-inducing conditions. In contrast, IFNgamma production was little affected. Failure to express IL-4 occurred even among cells that had gone through multiple cell divisions and was associated with a delay in the kinetics and magnitude of NFATc nuclear localization. IL-4 production was restored genetically by retroviral reconstitution of Itk or biochemically by augmenting the calcium flux with ionomycin. In vivo, Itk-deficient mice were unable to establish functional Th2 cells. Development of protective Th1 cells was unimpeded. These data define a nonredundant role for Itk in modulating signals from the TCR/CD28 pathways that are specific for the establishment of stable IL-4 but not IFNgamma expression. PMID 10549622 [PubMed - indexed for MEDLINE] Mice deficient in ITK have reduced proliferative responses to MHC stimulation and to anti-TCR cross-linking 1 Immunity. 1995 Dec;3(6) 757-69. Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk. Liao XC, Littman DR. Department of Microbiology and Immunology, University of California, San Francisco 94143-0414, USA. Itk is a T cell protein tyrosine kinase (PTK) that, along with Btk and Tec, belongs to a family of cytoplasmic PTKs with N-terminal pleckstrin homology domains. Btk plays a critical role in B lymphocyte development. To determine whether Itk has an analogous role in T lymphocytes, we used gene targeting to prepare mice lacking expression of Itk. Such animals had decreased numbers of mature thymocytes, an effect most clearly observed in mice expressing T cell receptor (TCR) transgenes. Mature T cells from Itk-deficient mice had reduced proliferative responses to allogeneic MHC stimulation and to anti-TCR cross-linking, but responded normally to stimulation with phorbol ester plus ionomycin or with IL-2. These results provide genetic evidence that Itk is involved in T cell development and also suggest that Itk has an important role in proximal events in TCR-mediated signaling pathways. PMID 8777721 [PubMed - indexed for MEDLINE] Mutations in Btk cause X-linked immunodeficiency. 1 Semin Immunol. 1998 Aug;10(4) 309-16. Btk function in B cell development and response. Satterthwaite AB, Li Z, Witte ON. Department of Microbiology and Molecular Genetics, University of California, Los Angeles 90095-1662, USA. Mutations in Bruton s tyrosine kinase (Btk) result in the B cell immunodeficiencies XLA in humans and Xid in mice. Both the maintenance of peripheral B cell numbers and their response to B cell antigen receptor (BCR) crosslinking depend on Btk. Btk integrates signals from multiple cell surface receptors, including BCR and G-protein coupled receptors. These Btk dependent signals control B cell proliferation and survival by mediating Ca2+ flux, activating JNK and p38 and inducing cell cycle regulatory genes. Publication Types Review PMID 9695187 [PubMed - indexed for MEDLINE] Gads(GRAP2) has a role in thymocyte proliferaction for maturation of T-cells. 1 Science. 2001 Mar 9;291(5510) 1987-91. Requirement for the SLP-76 adaptor GADS in T cell development. Yoder J, Pham C, Iizuka YM, Kanagawa O, Liu SK, McGlade J, Cheng AM. Medical Scientist Training Program, Washington University School of Medicine, St. Louis, MO 63110, USA. GADS is an adaptor protein implicated in CD3 signaling because of its ability to link SLP-76 to LAT. A GADS-deficient mouse was generated by gene targeting, and the function of GADS in T cell development and activation was examined. GADS- CD4-CD8- thymocytes exhibited a severe block in proliferation but still differentiated into mature T cells. GADS- thymocytes failed to respond to CD3 cross-linking in vivo and were impaired in positive and negative selection. Immunoprecipitation experiments revealed that the association between SLP-76 and LAT was uncoupled in GADS- thymocytes. These observations indicate that GADS is a critical adaptor for CD3 signaling. PMID 11239162 [PubMed - indexed for MEDLINE] Gads(GRAP2) has a role for homeostatic proliferaction in B cells. 1 Eur J Immunol. 2005 Apr;35(4) 1184-92. Expression and function of the adaptor protein Gads in murine B cells. Yankee TM, Draves KE, Clark EA. Department of Immunology, University of Washington, Seattle, USA. tyankee@kumc.edu Nearly all hematopoietic receptors are dependent on adaptor proteins for the activation of downstream signaling pathways. The Gads adaptor protein is expressed in many hematopoietic tissues, including bone marrow, lymph node, and spleen. Using intracellular staining, we detected Gads protein in a number cells, including B cells, T cells, NK cells, monocytes, and plasmacytoid DC, but not in macrophages, neutrophils, or monocyte-derived DC. In the B cell compartment, Gads was first expressed after immature B cells leave the bone marrow and was down-regulated after B cell antigen receptor (BCR) ligation. Female Gads(-/-) mice had increased numbers of splenic B cells, as compared to female Gads(+/+) mice, suggesting a role for Gads in B cell homeostasis. Although B cell production and turnover of splenic B cell subsets appeared normal in Gads(-/-) mice, homeostatic proliferation was significantly impaired in Gads(-/-) B cells. Whereas BCR ligation can induce apoptosis in wild-type transitional stage 1 (T1) B cells, Gads(-/-) T1 B cells were resistant to BCR-induced apoptosis. Gads(-/-) B cells also showed increased BCR-mediated calcium mobilization. We conclude that Gads may have a negative regulatory role in signaling through survival pathways, and is necessary for normal homeostatic proliferation in B cells. PMID 15761845 [PubMed - indexed for MEDLINE] Grap negatively regulates T-cell proliferation. 1 Mol Cell Biol. 2002 May;22(10) 3230-6. Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction. Shen R, Ouyang YB, Qu CK, Alonso A, Sperzel L, Mustelin T, Kaplan MH, Feng GS. Program in Signal Transduction Research, The Burnham Institute, La Jolla, California 92037, USA. Grb-2-related adaptor protein (Grap) is a Grb2-like SH3-SH2-SH3 adaptor protein with expression restricted to lymphoid tissues. Grap(-/-) lymphocytes isolated from targeted Grap-deficient mice exhibited enhanced proliferation, interleukin-2 production, and c-fos induction in response to mitogenic T-cell receptor (TCR) stimulation, compared to wild-type cells. Ectopic expression of Grap led to a suppression of Elk-1-directed transcription induced by the Ras/Erk pathway, without having effects on gene expression mediated by Jnk and p38 mitogen-activated protein kinases. Together, these data suggest that Grap, unlike Grb2, acts as a negative regulator of TCR-stimulated intracellular signaling by downregulating signal relay through the Ras/Erk pathway. PMID 11971956 [PubMed - indexed for MEDLINE] Gab2 is a substrate of ZAP-70 and functions as a switch molecule toward inhibition of TCR signal transuduction. 1 J Biol Chem. 2001 Nov 30;276(48) 45175-83. Epub 2001 Sep 25. Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules. Yamasaki S, Nishida K, Hibi M, Sakuma M, Shiina R, Takeuchi A, Ohnishi H, Hirano T, Saito T. Molecular Genetics, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan. To maintain various T cell responses and immune equilibrium, activation signals triggered by T cell antigen receptor (TCR) must be regulated by inhibitory signals. Gab2, an adaptor protein of the insulin receptor substrate-1 family, has been shown to be involved in the downstream signaling from cytokine receptors. We investigated the functional role of Gab2 in TCR-mediated signal transduction. Gab2 was phosphorylated by ZAP-70 and co-precipitated with phosphoproteins, such as ZAP-70, LAT, and CD3zeta, upon TCR stimulation. Overexpression of Gab2 in Jurkat cells or antigen-specific T cell hybridomas resulted in the inhibition of NF-AT activation, interleukin-2 production, and tyrosine phosphorylation. The structure-function relationship of Gab2 was analyzed by mutants of Gab2. The Gab2 mutants lacking SHP-2-binding sites mostly abrogated the inhibitory activity of Gab2, but its inhibitory function was restored by fusing to active SHP-2 as a chimeric protein. A mutant with defective phosphatidylinositol 3-kinase binding capacity also impaired the inhibitory activity, and the pleckstrin homology domain-deletion mutant revealed a crucial function of the pleckstrin homology domain for localization to the plasma membrane. These results suggest that Gab2 is a substrate of ZAP-70 and functions as a switch molecule toward inhibition of TCR signal transduction by mediating the recruitment of inhibitory molecules to the TCR signaling complex. PMID 11572860 [PubMed - indexed for MEDLINE] B cell signaling causes tyrosine phosphorylation of Gab1, and in turn SHP2 bind to Gab1 Gab1 phosophorylation potentiate the phosphorylation of Akt, PI3K-dependent response. 1 J Biol Chem. 2001 Apr 13;276(15) 12257-65. Epub 2001 Jan 22. The Gab1 docking protein links the b cell antigen receptor to the phosphatidylinositol 3-kinase/Akt signaling pathway and to the SHP2 tyrosine phosphatase. Ingham RJ, Santos L, Dang-Lawson M, Holgado-Madruga M, Dudek P, Maroun CR, Wong AJ, Matsuuchi L, Gold MR. Departments of Microbiology and Immunology and Zoology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. B cell antigen receptor (BCR) signaling causes tyrosine phosphorylation of the Gab1 docking protein. This allows phosphatidylinositol 3-kinase (PI3K) and the SHP2 tyrosine phosphatase to bind to Gab1. In this report, we tested the hypothesis that Gab1 acts as an amplifier of PI3K- and SHP2-dependent signaling in B lymphocytes. By overexpressing Gab1 in the WEHI-231 B cell line, we found that Gab1 can potentiate BCR-induced phosphorylation of Akt, a PI3K-dependent response. Gab1 expression also increased BCR-induced tyrosine phosphorylation of SHP2 as well as the binding of Grb2 to SHP2. We show that the pleckstrin homology (PH) domain of Gab1 is required for BCR-induced phosphorylation of Gab1 and for Gab1 participation in BCR signaling. Moreover, using confocal microscopy, we show that BCR ligation can induce the translocation of Gab1 from the cytosol to the plasma membrane and that this requires the Gab1 PH domain as well as PI3K activity. These findings are consistent with a model in which the binding of the Gab1 PH domain to PI3K-derived lipids brings Gab1 to the plasma membrane, where it can be tyrosine-phosphorylated and then act as an amplifier of BCR signaling. PMID 11278704 [PubMed - indexed for MEDLINE] RasGRP1 mediates Ras activation following TCR stimulatioin. RasGRP1 and RasGRP3 induces RAS activation in B-cell to response to T-cell stimulation. 1 Immunol Lett. 2006 May 15;105(1) 77-82. Epub 2006 Feb 20. The role of RasGRPs in regulation of lymphocyte proliferation. Coughlin JJ, Stang SL, Dower NA, Stone JC. Department of Biochemistry, University of Alberta, Edmonton, Alta., Canada T6G 2H7. RasGRP1 links TCR signaling to Ras in T cells, while both RasGRP1 and RasGRP3 link BCR signaling to Ras in B cells. T cells deficient in RasGRP1 have defective proliferative responses as do B cells deficient in both RasGRP1 and RasGRP3, confirming the importance of Ras activation in lymphocyte proliferation. While aged Rasgrp1-/- mice develop late-onset autoimmunity characterized by splenomegaly and the presence of anti-nuclear antibodies (ANA), the additional loss of RasGRP3 expression inhibits this phenotype. We show here that the autoimmunity in Rasgrp1-/- mice is T cell dependent. Compared to wildtype, Rasgrp1-/- T cells induce greater in vitro B cell proliferation that is due, at least in part, to increased production of interleukin-4 (IL-4). Rasgrp1 Rasgrp3 double mutant B cells are less responsive to this T cell stimulation. The reduced double mutant B cell proliferative response was paralleled by decreased induction of cyclin D2 upon stimulation with IL-4 and anti-IgM. Taken together these results suggest that double mutant mice fail to generate autoimmunity due to their decreased B cell cyclin D2 accumulation, and thus proliferation, in response to the elevated levels of IL-4 produced by mutant T cells. PMID 16530850 [PubMed - indexed for MEDLINE] Grb2-hSos1-PLCgamma1-p36/p38-ZAP70 complexes localize in the vicinity of TCR-zeta 1 J Biol Chem. 1995 Aug 4;270(31) 18428-36. Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR. Nel AE, Gupta S, Lee L, Ledbetter JA, Kanner SB. Department of Medicine, UCLA School of Medicine 90024, USA. Signaling by the T-cell antigen receptor (TCR) involves both phospholipase C (PLC)-gamma 1 and p21ras activation. While failing to induce Shc/Grb2 association, ligation of the TCR/CD3 receptor in Jurkat T-cells induced hSos1-Grb2 complexes. In addition to hSos1, Grb2 participates in the formation of a tyrosine phosphoprotein complex that includes 145-, 95-, 70-, 54-, and 36-38-kDa proteins. p145 was identified as PLC-gamma 1 and p70 as the protein tyrosine kinase, ZAP-70. Although of the same molecular weight, p95 was not recognized by an anti-serum to p95 Vav. The SH2 domains of Grb2 and PLC-gamma 1 were required for the formation of this protein complex. In anti-CD3-treated cells, Grb2 redistributed from the cytosol to a particulate cell compartment along with p36/p38, ZAP-70, and PLC-gamma 1. Part of the Grb2 complex associated with the particulate compartment could be extracted with Nonidet P-40, while the rest was Nonidet P-40 insoluble. In both the detergent-soluble and -insoluble fractions, Grb2 coimmunoprecipitated with the zeta-chain of the TCR. Taken together, these results indicate that anti-CD3 induces Grb2-hSos1-PLC-gamma 1-p36/p38-ZAP70 complexes, which localize in the vicinity of TCR-zeta. PMID 7629168 [PubMed - indexed for MEDLINE] Gads(Grap2) plays an important role in T-cell signaling via its association with SLP-76 and LAT. 1 Curr Biol. 1999 Jan 28;9(2) 67-75. The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Liu SK, Fang N, Koretzky GA, McGlade CJ. Department of Medical Biophysics, University of Toronto, The Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, Research Institute, 555 University Ave, Toronto, Ontario M5G 1X8, Canada. BACKGROUND The adaptor protein Gads is a Grb2-related protein originally identified on the basis of its interaction with the tyrosine-phosphorylated form of the docking protein Shc. Gads protein expression is restricted to hematopoietic tissues and cell lines. Gads contains a Src homology 2 (SH2) domain, which has previously been shown to have a similar binding specificity to that of Grb2. Gads also possesses two SH3 domains, but these have a distinct binding specificity to those of Grb2, as Gads does not bind to known Grb2 SH3 domain targets. Here, we investigated whether Gads is involved in T-cell signaling. RESULTS We found that Gads is highly expressed in T cells and that the SLP-76 adaptor protein is a major Gads-associated protein in vivo. The constitutive interaction between Gads and SLP-76 was mediated by the carboxy-terminal SH3 domain of Gads and a 20 amino-acid proline-rich region in SLP-76. Gads also coimmunoprecipitated the tyrosine-phosphorylated form of the linker for activated T cells (LAT) adaptor protein following cross-linking of the T-cell receptor; this interaction was mediated by the Gads SH2 domain. Overexpression of Gads and SLP-76 resulted in a synergistic augmentation of T-cell signaling, as measured by activation of nuclear factor of activated T cells (NFAT), and this cooperation required a functional Gads SH2 domain. CONCLUSIONS These results demonstrate that Gads plays an important role in T-cell signaling via its association with SLP-76 and LAT. Gads may promote cross-talk between the LAT and SLP-76 signaling complexes, thereby coupling membrane-proximal events to downstream signaling pathways. PMID 10021361 [PubMed - indexed for MEDLINE] Lck is required for normal signal transduction through the TCR. 1 Cell. 1992 Aug 21;70(4) 585-93. Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor. Straus DB, Weiss A. Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco 94143. Signaling through the T cell antigen receptor (TCR) results both in rapid increases in tyrosine phosphorylation on a number of proteins and in the activation of the phosphatidylinositol pathway. It is not clear how stimulation of the TCR leads to these signaling events. Mutants of the Jurkat T cell line have been previously isolated that fail to show increases in calcium following receptor stimulation. Analysis of one of these mutants, JCaM1, which is defective in the induction of tyrosine phosphorylation, revealed a defect in the expression of functional lck tyrosine kinase. The lack of lck activity was caused in part by a splicing defect. Expression of the lck cDNA in JCaM1 restores the ability of the cell to respond to TCR stimulation. These results indicate that lck is required for normal signal transduction through the TCR. PMID 1505025 [PubMed - indexed for MEDLINE] ZAP-70 plays crucial roles in T-cell activation and development. Syk triggers cellular activation in T-cell. 1 Mol Cell Biol. 1998 Mar;18(3) 1388-99. Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. Williams BL, Schreiber KL, Zhang W, Wange RL, Samelson LE, Leibson PJ, Abraham RT. Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA. T-cell antigen receptor (TCR) engagement activates multiple protein tyrosine kinases (PTKs), including the Src family member, Lck, and the Syk-related PTK, ZAP-70. Studies in ZAP-70-deficient humans have demonstrated that ZAP-70 plays crucial roles in T-cell activation and development. However, progress toward a detailed understanding of the regulation and function of ZAP-70 during TCR signaling has been hampered by the lack of a suitable T-cell model for biochemical and genetic analyses. In this report, we describe the isolation and phenotypic characterization of a Syk- and ZAP-70-negative somatic mutant derived from the Jurkat T-cell line. The P116 cell line displays severe defects in TCR-induced signaling functions, including protein tyrosine phosphorylation, intracellular Ca2+ mobilization, and interleukin-2 promoter-driven transcription. These signaling defects were fully reversed by reintroduction of catalytically active versions of either Syk or ZAP-70 into the P116 cells. However, in contrast to ZAP-70 expression, Syk expression triggered a significant degree of cellular activation in the absence of TCR ligation. Transfection experiments with ZAP-70-Syk chimeric proteins indicated that both the amino-terminal regulatory regions and the carboxy-terminal catalytic domains of Syk and ZAP-70 contribute to the distinctive functional properties of these PTKs. These studies underscore the crucial role of ZAP-70 in TCR signaling and offer a powerful genetic model for further analyses of ZAP-70 regulation and function in T cells. PMID 9488454 [PubMed - indexed for MEDLINE]
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Petition例文 EVE Online中AZ2.0社及びその関連企業内で起きた事例のPetition例文集です。 稚拙な文ですが、御参考まで^^; プレイヤーの言語能力の如何に関わらず、運営は当事者からのPetitionしか対応してくれません。 「英語に問題があるから~」と述べた上で代理Petiしても「本人にPetiさせろ」の一言で片づけられてしまいます Petition例文キャラクターがスタックしログイン出来ない場合 サーバー不調等の原因により消失した艦船を補填してもらう場合 クレジットカード登録時エラーが出て課金処理が出来ない場合 不当な理由によりキャラクターがBANされた場合 移動予定のエージェントが応対してくれない場合 他プレイヤーのハラスメントを訴えたい場合 Petitionしても対応されなかったケースMarket不調による購入物の重複 キャラクターがスタックしログイン出来ない場合 (区分 Group Stuck, Category Stuck Characters) ■例文 My character, (キャラ名) got stuck in (スタックしたシステム名) and cannot get log in back. Please kindly move it to (移動先システム名) so I can continue my journey to my destination. Your soonest assistance will be much appreciated. Thank you. ■大意 私のキャラクター(キャラ名)が(スタックしたシステム名)でスタックしログインする事が出来ません 目的地への旅が続けられる様(移動先システム名)へ移動して下さい。出来る限り早い対応をお願いします ■補足 2008年10月16日現在、交通量の多いシステムでスタックした場合クライアント側で移動先を指定できる様になっています 移動先システムはスタックしたシステムの隣接システムを指定して下さい(試しに3J先でお願いしたらダメって言われましたw) サーバー不調等の原因により消失した艦船を補填してもらう場合 (区分 Group Reimbursment, Category Ships Combat) ■例文 Due to (原因) happened (時間), I lost my (対象艦船) in (場所) as it went out of control. I would like to apply for reimbursment to restore what I had before this mess. I would like your immediate attention on my case and wish all of investigations and the reinmbursment will be done soon. Thank you. ■大意 (時間)に起きた(原因)により操作不能になり、(場所)で(対象艦船)を失いましたので、当問題の発生以前の状態に戻して頂きたく補填を申請します 早急な対応をお願いすると共に調査と補填が速やかに処理される事を願います ■補足 (原因)はTerrible Lag(ひどいラグ)やSystem Crush(システムのクラッシュ)等 (時間)は30 minutes ago(30分前)やYesterday(昨日)等 補填の処理は数日から長いもので数ヶ月かかります(弊社員の場合は5日かかりました) 補填はあくまでシステム側に問題があった場合のみ対応の様です 残骸に残った装備品や積載品は補填の対象外です。補填されるのは艦船消失時に失った物のみ クレジットカード登録時エラーが出て課金処理が出来ない場合 (区分 Group Billing Account Category Payment Methods Subscription Costs) ■例文 I have problem with the subscription using my credit card. Please kindly advise how I can solve the problem and activate my account. The error message shows in the subscription page is as following (課金ページのエラーメッセージをコピペ) ■大意 クレジットカードを使っての登録に問題が有り課金処理ができません。 どの様にすれば問題を解決しアカウントを有効にできるかアドバイスをお願いします。 課金ページで表示されるエラーは以下の通りです (エラーメッセージのコピペ) ■補足 課金時の情報登録ではピリオド(.)やコンマ(,)は使えないようです 不当な理由によりキャラクターがBANされた場合 (区分 Group Stuck Category Stuck Character)GMが常にいるカテゴリーの為迅速な対応が望める(かも) ■例文 My character; (キャラクター名) was recently BANed due to suspicion of (容疑) which I have never done before. I seriously protest against this unjust BAN, and demand for immediate investigation to restore my character and all property I owned. ■大意 最近身に覚えの無い(容疑)を理由に私のキャラクターがBANされました。 当の不当なBANに対して抗議すると共に迅速な調査及びキャラクターとその財産の復活を要求します。 ■補足 もちろん利用規約に反した行動をした場合は相手にされません^^; 関連Corp社員がRMT業者の一斉BANに巻き込まれ、身に覚えの無いRMT容疑でBANされた事があり、キャラクターが復活されるまで2,3日かかりました。 GMからは「キャラクター戻しました。ごめんね」とふざけたメールのみ。以降どうするかは各自で判断を^^; (容疑)はBANされた時に通知がきますので、その通知よりコピペ。 移動予定のエージェントが応対してくれない場合 (Group Stuck Category Stuck Character)他にそれらしいのが無いのでこれでOKだと思います。 ■例文 I cannot reject a offered mission from agen named (エージェント名) for neither of accepting or rejecting options do not show in agent dialog window. Please reject the offer or simply reset it for me before it harms my standings by its due. Your soonest assistance will be much appreciated. ■大意 移動予定のエージェントとの会話窓にてミッション受諾・拒否の選択肢が表示されない為、オッファーされたミッションを拒否する事ができません。期限切れでスタンディングが低下する前にミッションを拒否するか単純にオッファー自体をリセットして下さい。早期の対応をお願いします。 ■補足 ミッションをリセットする事で対応してくれます。 他プレイヤーのハラスメントを訴えたい場合 (Group Rules Policies Category Harassment) ■例文 I would like to accuse a player named (対象プレイヤー名) for his/her serious harassment. Your immediate and due attention is much required to this case as his harassment is retarting my game play. (ハラスメントの内容:多岐に渡る為お近くの方にお聞き下さい^^;) ■大意 深刻なハラスメント行為により(対象プレイヤー名)を告発します。 当のハラスメントにより私のプレイが阻害されている為、迅速且つ適切な対応を要求します。 (ハラスメントの内容) ■補足 「いつ」「どこで」「何をした」と詳細を聞かれます。内容はなるべく具体的に。 規約内の行為であれば基本的に相手にしてもらえません^^; 弊社員がアステロイドベルトにて4,5時間の間ワープの妨害等を受け続けクレームを出しましたが規約範囲内の行為なので何もできないとの事でした。 Petitionしても対応されなかったケース Market不調による購入物の重複 ■状況 マーケットの不調でBUY ITEMをしてもwalletアイコンは点滅するものの口座からお金が引き落とされずアイテムも納入されませんでした。 PCの再起動・再ログイン・別回線・別PCでもサーバーの様子を確認しましたがマーケット以外は通常に機能しており明らかにサーバー側の原因によるものでした。 BUY ITEMを数度試してみましたが全く反応がなく15分程して一気に試した回数分の取引が行われた為、リファンドをしてもらう様Petitionしました。 ■CCP返答 「目的の品は既に手に入れているので対応しません。重複した物は自分で処理して下さい。」 ■補足 ログを確認すればすぐにわかる様な気がしますが、Petitionした本人が最初の返答で対応せずの結果を出してきたGMに抗議しても 意味無しと判断し以降の抗議等はしませんでした。マーケットが反応しない場合は下手に操作を繰り返さず暫く待ってみる事をお勧めします。 EVE-Online™ and EVE imagery © CCP.
https://w.atwiki.jp/maniacool/pages/10.html
Comment corrigez-vous cela? Vous créez beaucoup de bruit supplémentaire. C’est essentiellement ce qu’est un brouilleur de signal. En fonction du type de signal que vous essayez de bloquer, le brouilleur créera suffisamment de bruit pour disperser le reste sur cette longueur d onde. Pensez-y comme ceci si vous amenez un groupe de personnes dans cette grande pièce, le bruit des secrets murmurés est noyé. Certains brouilleurs agissent comme une personne qui crie qui crie dans l oreille de quiconque tente d écouter. Ils aident à protéger vos informations en s assurant que les données sont cryptées ou indéchiffrables par les pirates potentiels. Protéger les données même lorsque vous êtes hors ligne Beaucoup de gens ont l impression que si un ordinateur est éteint ou hors ligne, les informations qu il contient sont alors protégées. Si seulement c était le cas! Au lieu de cela, les pirates peuvent utiliser la technologie et les astuces pour voler des données à une courte distance. C’est là que le brouilleur entre en scène! Les brouilleurs de signaux peuvent être utilisés pour empêcher toute personne d utiliser son téléphone portable à une distance supérieure à 20 mètres. Ils peuvent être utilisés pour bloquer les signaux wifi et empêcher que des données ne soient arrachées de l’air. Même lorsque vous n êtes pas au bureau ou que les ordinateurs ne fonctionnent pas, les brouilleurs à proximité arrêteront les fuites de données en créant une tempête constante de bruit de fréquence. http //www.mania-cool.com/17-brouillage-de-haute-puissance
https://w.atwiki.jp/api_programming/pages/129.html
下位ページ Session Content #conten Module Toybox ActivityRecording Overview The Activity Recording module will allow Apps to access the FIT file recording capabilities of the device. Apps can use this module to allow the user to start and stop recordings, create laps, and save recorded data. Since 1.0.0 App Types App Requires Permission Fit Defined Under Namespace Classes Session Constant Summary The SPORT enum allows definition of what kind of sport is being recorded.Use SPORT_GENERIC for sports not on the list. SPORT_GENERIC = 0 Since 1.0.0 SPORT_RUNNING = 1 Since 1.0.0 SPORT_CYCLING = 2 Since 1.0.0 SPORT_TRANSITION = 3 Sport used for mulitsport transitions. Since 1.0.0 SPORT_FITNESS_EQUIPMENT = 4 Sport used for ANT enabled excercise equipment. Since 1.0.0 SPORT_SWIMMING = 5 Since 1.0.0 SPORT_BASKETBALL = 6 Since 1.0.0 SPORT_SOCCER = 7 Since 1.0.0 SPORT_TENNIS = 8 Since 1.0.0 SPORT_AMERICAN_FOOTBALL = 9 Since 1.0.0 SPORT_TRAINING = 10 Sport used for activities such as strength training, cardio, etc Since 1.0.0 SPORT_WALKING = 11 Since 1.0.0 SPORT_CROSS_COUNTRY_SKIING = 12 Since 1.0.0 SPORT_ALPINE_SKIING = 13 Since 1.0.0 SPORT_SNOWBOARDING = 14 Since 1.0.0 SPORT_ROWING = 15 Since 1.0.0 SPORT_MOUNTAINEERING = 16 Since 1.0.0 SPORT_HIKING = 17 Since 1.0.0 SPORT_MULTISPORT = 18 Since 1.0.0 SPORT_PADDLING = 19 Since 1.0.0 SUB_SPORT_GENERIC = 0 Sub-sports allow for clarification of sport when recording. Use SUB_SPORT_GENERIC if no other sub-sport is applicable. Since 1.0.0 SUB_SPORT_TREADMILL = 1 Sub-sport for Running and Fitness Equipment Since 1.0.0 SUB_SPORT_STREET = 2 Sub-sport for Running Since 1.0.0 SUB_SPORT_TRAIL = 3 Sub-sport for Running Since 1.0.0 SUB_SPORT_TRACK = 4 Sub-sport for Running Since 1.0.0 SUB_SPORT_SPIN = 5 Sub-sport for Cycling Since 1.0.0 SUB_SPORT_INDOOR_CYCLING = 6 Sub-sport for Cycling and Fitness Equipment Since 1.0.0 SUB_SPORT_ROAD = 7 Sub-sport for Cycling Since 1.0.0 SUB_SPORT_MOUNTAIN = 8 Sub-sport for Cycling Since 1.0.0 SUB_SPORT_DOWNHILL = 9 Sub-sport for Cycling Since 1.0.0 SUB_SPORT_RECUMBENT = 10 Sub-sport for Cycling Since 1.0.0 SUB_SPORT_CYCLOCROSS = 11 Sub-sport for Cycling Since 1.0.0 SUB_SPORT_HAND_CYCLING = 12 Sub-sport for Cycling Since 1.0.0 SUB_SPORT_TRACK_CYCLING = 13 Sub-sport for Cycling Since 1.0.0 SUB_SPORT_INDOOR_ROWING = 14 Sub-sport for Rowing and Fitness Equipment Since 1.0.0 SUB_SPORT_ELLIPTICAL = 15 Sub-sport for Fitness Equipment Since 1.0.0 SUB_SPORT_STAIR_CLIMBING = 16 Sub-sport for Fitness Equipment Since 1.0.0 SUB_SPORT_LAP_SWIMMING = 17 Sub-sport for Swimming Since 1.0.0 SUB_SPORT_OPEN_WATER = 18 Sub-sport for Swimming Since 1.0.0 SUB_SPORT_FLEXIBILITY_TRAINING = 19 Sub-sport for Training Since 1.0.0 SUB_SPORT_STRENGTH_TRAINING = 20 Sub-sport for Training Since 1.0.0 SUB_SPORT_WARM_UP = 21 Sub-sport for Activity Warm-up Since 1.0.0 SUB_SPORT_MATCH = 22 Sub-sport for Sports with Matches (e.g. Tennis) Since 1.0.0 SUB_SPORT_EXERCISE = 23 Sub-sport for Excercise Since 1.0.0 SUB_SPORT_CHALLENGE = 24 Sub-sport for a Sport Challenge Since 1.0.0 SUB_SPORT_INDOOR_SKIING = 25 Sub-sport for Fitness Equipment Since 1.0.0 SUB_SPORT_CARDIO_TRAINING = 26 Sub-sport for Training Since 1.0.0 Instance Method Summary (collapse) - (Session) createSession(options) Use createSession() to create a session object with options determined by the caller. Instance Method Details (Session) createSession(options) Use createSession() to create a session object with options determined by the caller. Only one session object is allowed to exist at a time. If there is an existing object that has not been closed using the save() or discard() methods, this method will return that object instead of creating a new one. Parameters options (Dictionary) — A Dictionary containing session creation options Options Hash (options) sport (Object) — The primary sport being recorded (SPORT_GENERIC by default) subSport (Object) — The sport subcategory being recorded (SUB_SPORT_GENERIC by default) name (String) — Required. This is the name that will be associated with the sport being recorded. The suggested maximum length of the name is 15 characters (some devices support longer names). Returns (Session) — A new session object, or the existing session object if a session is active and has not been saved or discarded Since 1.0.0
https://w.atwiki.jp/momonemomo_en/pages/26.html
This English translation is for reference. Any questions arising shall be settled by the original Japanese text given here. Updated on October 18, 2010 Non-commercial Works (Private or Fan-circle/Doujin Works) The character Momone Momo is free of use including comics, illustrations, animations, figurines cosplay designs and/or sundries. Prior acknowledgment is not necessarily required. Commercial Works Prior permission is required when using the character Momone Momo for commercial use. Reminders (1) Do not use the character Momone Momo for articles which include strongly political, violent and/or obscene expressions. (2) The character Momone Momo belongs to the voice bank Momone Momo and the author Fujimoto Momoko only. No other voice bank or source should be attached to this character. This guideline seen here may be subject to change without prior notice. Please adhere the latest version of the usage clause. ☆Note Though not obligatory, your acknowledgment will be appreciated when broadcasting your works in the mediums other than on Nicovideo or YouTube, or when distributing comics and/or figurines.
https://w.atwiki.jp/xboxonescore/pages/886.html
Curious Expedition 項目数:60 総ポイント:1000 難易度: Out of the way! Blow up 50 mountains 10 The Reanimator Revive 10 trek members at altars 10 Beyond the gate Stay inside a portal for 100 days 10 Auctioneer Sell items worth 100000 funds 10 This belongs in a museum Donate items worth 100000 fame 10 Chocolate addict Eat 500 chocolate rations 10 Entomologist Collect 50 butterflies 10 Art Collector Collect 50 paintings 10 Anthropologist Collect 50 anthropological studies 10 Bring shovels! Find and dig up 10 treasures 10 Curious Explorer Unlock 13 explorers 10 A good heart is hard to find Finish at least third place without your standing ever dropping below zero 10 Party Train Have at least 3 members of your trek be alcoholics 10 Fight fire with fire Blow up an active volcano with dynamite 10 Triple Trouble How many abominations can you handle? 10 Fame without fortune Finish at least third place without selling anything 10 Trippy Trip Finish at least third place using no sanity item other than coca leaves 10 Abort! Abort! Use your hot air balloon to escape an expedition 10 Adventure awaits! Survive the tutorial 10 No new friends Finish at least third place and recruit nobody at the harbor or villages 10 History will forget you Finish a full game in 3rd place 10 Second winner is first loser Finish a full game in 2nd place 60 And here is your statue Finish a full game in 1st place 160 Dedicated Explorer Obtain 19 golden frames 10 Obsessive Explorer Obtain 19 platinum frames 60 A collector of sorts Find all items 60 World 2 Reach World 2 10 World 3 Reach World 3 10 World 4 Reach World 4 10 World 5 Reach World 5 10 World 6 Reach World 6 60 Adventurous Spirit Succeed in 100 expeditions. 60 Interdimensional traveler Travel through 20 portals 10 Xenophil Recruit 20 natives 10 Special Visit Visit 5 different special regions 10 Dinotopia Recruit 20 dinosaurs 10 I just can t say no Complete 20 harbor quests 10 Snarfrattle must die Hunt down and kill the legendary hyena 10 Legendary Headbutt a raptor 10 Nope! Flee 10 times from combat 10 Hyena Hunter Kill 100 hyenas 10 Liberator Defeat a slave trader and free the slaves 10 Crocodile Dundee Kill 20 crocodiles 10 Giant giant chicken dinner Kill 10 giant birds 10 There is no weak spot Kill a giant crab 10 Scorpion King Kill 10 giant scorpions 10 Treasure Hunter Obtain 100 treasure items 10 Arachnophobia Kill 20 giant spiders 10 Breeder Hatch 10 eggs 10 Walrus hunter Kill 10 giant walruses 10 秘密の実績 Corrupted King Find the unholy blood crown 10 Secret Session Finish at least third place with a secret explorer 10 Hungry Heart True lovers don t eat their loved ones 10 Schroedingers Box I just want to make sure the cat is fine 10 Cold Companion Find an extraordinary friend 10 A tribute to Yama Return what belongs to an altar 10 Made for battle Obtain a rare creature from the beast master 10 What lies beneath A chalice awaits beyond the face 10 Pattern recognition There is something to find in every region 10 Ballooning Seeing London from above 10
https://w.atwiki.jp/dow2jpmodwiki/pages/84.html
9108439Consume mass quantities! 9108440Tyranid Termagant 9108441Termagant 9108442Gauntii Virago 9108444%1CATEGORY% Events 9108445Fine Destructor 9108446Fine Destructor 9108447Sector 9108448Rending 9108449Fine Destructor 9108450Click and target direction 9108451Runes of Reaping 9108452Runes of Reaping 9108453Anointed Power Axe 9108454Victory reduces planetary infestation (-1) 9108455Stimulants accelerate a Space Marine’s superhuman healing, restoring Health and reviving incapacitated squad leaders. 9108456Stimulants accelerate a Space Marine’s superhuman healing, restoring Health and reviving incapacitated squad leaders. 9108457Stimulants accelerate a Space Marine’s superhuman healing, restoring Health and reviving incapacitated squad leaders. 9108458Stimulants accelerate a Space Marine’s superhuman healing, restoring Health and reviving incapacitated squad leaders. 9108459Stimulants accelerate a Space Marine’s superhuman healing, restoring Health and reviving incapacitated squad leaders. 9108460Explosives that can be planted ahead of time. Enemy infantry approaching the mine triggers its detonation, dealing significant damage. Cluster mines require almost no time to plant. 9108461Sophisticated targeting device which allows calling in precision strikes from Imperial Guard artillery positions. 9108462Beacon allowing for the deployment of Tarantula automated sentry guns at designated positions. 9108463Imperial relic that can render all your squads invulnerable for a brief time. 9108467Speshul Shoota 9108468Close-range Shotgun effective against infantry. Also grants the High Explosive Shells ability. 9108469Equip heavy shooter 9108470Travel to Selected Planet. 9108471Represents the degree to which the Tyranid invasion has affected this planet. Complete Tyranid missions and hold strategic assets on this planet to lower it. 9108472Active distress signal. You must travel to the selected planet in order to deploy to the mission. 9108473The planet you re currently orbiting and its status. 9108474View an overview of the desert world, Calderis. 9108475View an overview of the sub-sector capital, Meridian. 9108476View an overview of the jungle planet, Typhon Primaris. 9108477Close the Star Map. 9108478View the most pressing campaign goals that require your attention in detail. 9108479Review the Event Log to keep track of all recent events across Sub-Sector Aurelia. Gameplay tips can also be reviewed here. 9108480View the recent events on Calderis. 9108481View the recent events on Typhon Primaris. 9108482View the recent events on Meridian. 9108483Close the Event Log. 9108484Exit and save your current campaign. 9108485Force Commander 9108486Open the Squad Loadout Screen 9108487Tarkus 9108488Avitus 9108489Cyrus 9108490Thaddeus 9108491Davian Thule 9108492Campaign Rank 9108493Your current rank to the people of Subsector Aurelia. Open for more details. 9108494The planet you re currently orbiting, its status, and the state of Tyranid Infestation. 9108495Your overall campaign score. Defeat enemies and hold strategic assets to increase it. 9108496Deploy to current mission. 9108497Confirm current deployment selection. 9108498Tyranid Infestation 9108499AND 9108500Star Map 9108501Squad Loadout Screen 9108502Squad Deployment Screen 9108503Close the Planet Overview screen. 9108504Save the current campaign s progress. 9108505Save the current campaign s progress and return to the Main Menu Screen. 9108506Save the current campaign s progress and close the game. 9108507High Explosive Shells 9108508Volatile shells that deal devastating damage. 9108509Volatile shells that deal devastating damage. 9108510Click and select a target 9108512Adjust all settings to predefined values. 9108513OR 9108514Level 2 Webway Assembly 9108515Shimmer Orb 9108516All units inside the orb are immune to ranged damage, but are unable to fire their own ranged weapons for the duration of the effect. 9108517Equip accessory 9108518Improved Targeters 9108519Close the Menu. 9108520Select this squad. Click tab twice to focus your view on this leader. 9108521Improved Targeters 9108522Not Logged In 9108523Predefined Settings 9108524Close the Accolades Screen. 9108525Close the Squad Screen, accepting all changes to your squads. 9108526You cannot dispose of this item 9108527View gameplay tips. 9108528View all recent events and gameplay tips. 9108529View the recent events in Sub-Sector Aurelia. 9108530Heavy Bolter 9108531Terminator Armor 9108533Level 2 Webway Assembly 9108534The number of solar days that have passed in the Aurelian Campaign. 9108535Close the Mission Briefing Screen. 9108536Stikkbombs 9108537Close the Goal Briefing Screen. 9108538Battery Pack 9108539Increases the maximum energy of the Mek and grants the Ave A Taste ability, which allows the Mek to give Energy and Health to friendly units. 9108540Equip accessory 9108541Seismic Roar 9108542Area effect attack that knocks back enemies and poisons the immediate area. 9108543Charge 9108544Charge at targeted location, knocking over everything in the charge path. 9108545Click and target area 9108547Orbital Bombardment 9108548Call in a massive orbital strike capable of destroying even the heaviest units. 9108549Click and target area 9108550Add a Stamina point, increasing maximum Health and Health Regeneration. 9108551Add a Ranged point, increasing overall Ranged Damage. 9108552Add a Strength point, increasing overall Melee Damage and Melee Skill. 9108553Add a Will point, increasing maximum Energy and Energy Regeneration. 9108554Undo all recently spent Combat Discipline Points on this squad. 9108555Experience Bar 9108556The squad s progress towards the next level. 9108558Stamina Points 9108559The total points spent on Stamina. Each point increases Health and Health Regeneration and can unlock special traits for that squad. 9108560Ranged Points 9108561The total points spent on Ranged. Each point increases overall Ranged Damage and can unlock special traits for that squad. 9108562Strength Points 9108563The total points spent on Strength. Each point increases overall Melee Damage and Melee Skill and can unlock special traits for that squad. 9108564Will Points 9108565The total points spent on Will. Each point increases Energy and Energy Regeneration and can unlock special traits for that squad. 9108566Terminator Power Fist 9108567Terminator Power Fist 9108568Can Only be Replaced, Not Removed 9108571Storm Bolter 9108572Storm Bolter 9108573Can Only be Replaced, Not Removed 9108574Terminatus-pattern. The storm bolter is a mighty double-barreled bolter held in a single hand of a Terminator. It brings undaunted fury to the enemy and is highly effective against infantry targets. 9108575Level 2 Webway Assembly 9108576Enhanced Warp Jump Generator 9108577Reduces Teleport cooldown and increases Teleport range. Increases health of the Warp Spider Exarch. 9108578Equip armor 9108579Strategic Point 9108580Build this for additional power resource 9108581Increase power resource rate 9108582Power Add-on 9108583Power Add-on 9108584Psychic Shield 9108585Create a force field of psychic energy that protects the Warlock. 9108586Activate aura 9108587Champions Robe 9108590Activate aura 9108591Champions Robe 9108592Orbital Bombardment 9108593Call in a massive orbital strike capable of destroying even the heaviest units. 9108594Call in a massive orbital strike capable of destroying even the heaviest units. 9108595Click and target area 9108596Throw grenade to temporarily stun enemy units, preventing them from moving or firing. 9108597Cover an area with a devastating hail of high-explosive shells. 9108598Cover an area with a devastating hail of shells. 9108599Give in to righteous fury and become temporarily invulnerable. 9108601Call down a barrage from allied Imperial Guard artillery positions. 9108602Call down a barrage from allied Imperial Guard artillery positions. 9108603Call down a Drop Pod, reinforcing any nearby squad with a conscious sergeant. 9108604Call down a fiery artillery strike from allied Imperial Guard positions. Burning areas do damage to all infantry. 9108605Call down a fiery artillery strike from allied Imperial Guard positions. Burning areas do damage to all infantry. 9108606Deploy mines at the designated location. Enemy troop proximity triggers the mines. 9108607Deploy a Tarantula sentry gun at the designated location. Heavy bolter turret damages and suppresses enemy infantry. 9108608Click and target area 9108610Slam the Dreadnought s mighty fist into the ground, damaging, knocking back and temporarily stunning enemies. 9108611Tyranid Warrior Boss 9108612Consume mass quantities! 9108613Tyranid Warrior 9108614Warrior 9108615Tyranicus Gladius 9108616Smash! Maim! Destroy! 9108617Tyranid Venomspitter Carnifex 9108618Lesser Carnifex with Venom Cannon 9108619Tyranicus Chameleo 9108621Razorback Heavy Bolter 9108622Activate a force field that absorbs damage by draining Energy. 9108623Slam the Dreadnought s mighty fist into the ground, damaging, knocking back and temporarily stunning enemies. 9108624Not usable with %1WARGEARTAG% 9108625Requires %1WARGEARTAG% 9108626Eliminate the Eldar on Typhon 9108627Find the Techpriest Camp on Typhon 9108630Warp Spider Armor - Common 9108631Warp Spider Armor - Epic 9108632Warp Spider Armor - Rare 9108633Eldar Shuriken Turret 9108634Shuriken Cannon 9108635Building 9108636Click an area then choose firing arc 9108637Plasma Cannon 9108638Jump Pack 9108639Plant an explosive which can be triggered remotely. Deals heavy damage to all targets in blast radius. 9108640Warpspider Armor 9108641Ranger Armor - Common 9108642Ranger Armor - Epic 9108643Ranger Armor - Rare 9108645Infestation (per point each day) 9108646Activate homing device, allowing reinforcements to be teleported directly to Cyrus s location. 9108649Complete "Greenskin Weaponsmith" 9108650Complete "Stolen Armor" 9108651Anointed Power Axe 9108700Capturing a Communications Relay on a planet will allow emplaced Planetary Defense Forces to focus Artillery Strikes to a specified location. 9108701Automated Foundries can be found on many worlds, assisting in the production of arms and munitions while serving the various needs of the populace. Securing them will grant additional support and allow the directed deployment of Tarantula Turrets during a mission. 9108702Shrines to the Emperor of Man dot the surface of many worlds and many believe are a direct conduit to the divine grace of the Golden Throne. The sanctity of these shrines is of the upmost importance and retaking them will allow for the channeling of their power to any squads deployed on the field of battle. 9108706Creates a large psychic storm, disrupting and damaging enemies in a large radius 9108708Battle Standard 9108709Bolter 9108710Iron Halo 9108711Missile Launcher 9108712Power Armor 9108713Scout Armor 9108714Sniper Rifle 9108715Teleport Pack 9108772Vanguard of the Hive 9108802Hive Infestation 9108864Victory reduces infestation (-3) 9108867Tyranid Carnifex Boss 9108868Smash! Maim! Destroy! 9108869Tyranid Carnifex 9108870Carnifex Alpha 9108871Tyranicus Voracio 9108878Nesting 9108879+5 Infestation on Expiry 9108880Advance to the next page of saved campaigns. 9108881Return to the previous page of saved campaigns. 9108882%1Planet% Infestation Increased 9108883Planetary Infestation +5 9108884Planetary Infestation +6 9108885Planetary Infestation +7 9108886Planetary Infestation +8 9108887Planetary Infestation +9 9108888Planetary Infestation +10 9108889A Hive Tyrant has successfully created a new hive on %1PLANET%. This has caused a large increase in the planet s infestation. 9108890Confirm campaign deletion - this action cannot be undone. 9108891Cancel this action. 9108892View Planetary Details 9108893Building 9108894Ravener Tunnel 9108895Pro Logic 9108896Piercing 9108897Fearful Evolution 9108903Grav Platform 9108904Mekboy 9108905Build Structures 9108906Click to build structures. 9108907Toggle on/off 9108908Charge 9108909Temporarily increase Dreadnought s movement rate. 9108918Plasma Cannon 9108920Deffgun 9108921Equips the Mek with a Deffgun. Effective against infantry. This weapon has limited firing arc and requires setup time. 9108922Equip heavy weapon 9108923Big Shoota 9108924Level 2 Teleporta Platform 9108925Beamy Deffgun 9108926Equips the Mekboy with a Beamy Deffgun. Effective against vehicles and large targets. This weapon has limited firing arc and requires setup time. 9108927Equip heavy weapon 9108930Command Teleport Pack; allows a Force Commander to forgo the need to approach the enemy in a frontal assault, relocating through the Warp. 9108931Strategic Asset 9108932Costly Loss/Expiry 9108933Succeed or lose the Array 9108934Numerous Howling Banshees are part of the war host. 9108935Weapons platforms can do heavy damage to generators. 9108940Limit 1 9108941Huge Hammer 9108942Level 2 Teleporta Platform 9108943Warp Spiders may teleport to attack from the rear. 9108944Ripper swarms are vulnerable to flames. 9108945Tyranids with Barbed Stranglers can suppress defenders. 9108946Eldar Rangers may provide sniper support from long range. 9108947A powerful beast leads the swarm. 9108948The war host is led by an especially potent Eldar. 9108949The marauding Orks are led by an uncharacteristically strong boss. 9108950Ork burnas and rokkits pose a threat to the generators. 9108951Eldar laser technology is lethal to the generators. 9108952Spore mines and psychic blasts can destroy generators. 9108953Explosives can cause collateral damage to generators. 9108954Orks may fall back but will regroup and return. 9108955Ork Stikkbommaz target units in cover or buildings. 9108956Rites of Repair can restore damaged generators and turrets. 9108957Rites of Repair 9108960Recovery Accessory 9108961Repairs vehicles, turrets, and generators 9108962Rites of the Machine God that allow for the field repair of vehicles, power generators and Tarantula sentry guns. 9108963Succeed or lose the Foundry 9108964Succeed or lose the Shrine 9108965Burrow 9108966Burrow underground. Burrowed units cannot be seen except by enemy detectors. When the Ravener unburrows it knocks away any nearby enemies. 9108967Click to activate 9108968Super-Elite 9108969Enemy forces are very powerful. 9108970NPC Loota Boy Armor - Epic 9108971MK VII Aquila Armor 9108972Armor Rating 2 9108973DEFAULT Armor 9108974Can Only be Replaced, Not Removed 9108975NPC Loota Boy Armor - Epic 9108976MK VII Aquila Armor 9108977Armor Rating 2 9108978DEFAULT Armor 9108979Can Only be Replaced, Not Removed 9108980Secure and hold strategic assets across the sub-sector 9108982Hold the Sector (%1SOFAR%/%2TOTAL% days) 9108983Hold the sub-sector until the Litany of Fury arrives with the Chapter fleet. 9108984Orbital Bombardment 9108985Call in a massive orbital strike capable of destroying even the heaviest units. 9108986Call in a massive orbital strike capable of destroying even the heaviest units. 9108987Click and target area 9108992Only one use. 9108993Play Cooperatively? 9108995Yes (%1SecondsRemaining%) 9108996No 9108998Plasma Cannon 9108999Plasma Cannon 9109000Adrenal Gland Warrior 9109001Astartes MK Vb 9109002340 Damage 9109003Adrenal Gland Hormagaunt Termagant 9109004Astartes MK Vb 9109005340 Damage 9109006Adrenal Gland Hive Tyrant 9109007Astartes MK Vb 9109008340 Damage 9109009Can project a force field that uses Energy to absorb damage 9109010Can project a force field that uses Energy to absorb damage 9109012Can project a force field that uses Energy to absorb damage 9109013Can project a force field that uses Energy to absorb damage 9109014Can project a force field that uses Energy to absorb damage 9109015Can project a force field that uses Energy to absorb damage 9109016Can project a force field that uses Energy to absorb damage 9109017Can project a force field that uses Energy to absorb damage 9109018Can project a force field that uses Energy to absorb damage 9109019Can project a force field that uses Energy to absorb damage 9109020Can project a force field that uses Energy to absorb damage 9109021Grants the Teleport ability 9109022Grants the Teleport ability 9109023Grants the Teleport ability 9109024Grants the Teleport ability 9109025Grants the Teleport ability 9109026Grants the Teleport ability 9109027Grants the Teleport ability 9109028Grants the Teleport ability 9109029Grants the Teleport ability 9109030Grants the Teleport ability 9109031Grants the Teleport ability 9109032Grants the Teleport ability 9109033Grants the Teleport ability 9109034Grants the Teleport ability 9109035Grants the Rally ability 9109036Grants the Rally Ability 9109037Grants the Rally ability 9109038Grants the Rally ability 9109039Grants the Rally ability 9109040Grants the Rally ability 9109041Grants the Rally ability 9109042Grants the Rally ability 9109043Grants the Rally ability 9109044Grants the Rally ability 9109045Grants the Rally ability 9109046Grants the Rally ability 9109047Now I m Angry 9109048Boost the damage you do. (Damage to the Warboss charges this ability.) 9109049Click to activate 9109050Click to activate 9109051Disruptive melee unit 9109052Infantry 9109053Infantry 9109054Click and target area 9109055Imperial Guardsman 9109056Imperial Guardsman 9109057Imperial Guardsman 9109058Imperial Guardsman 9109059Imperial Guardsman 9109063Imperial Guard Squad 9109064Light Infantry 9109067Storm Trooper Squad 9109068Veteran Infantry 9109081Purification Rites 9109082When the Apothecary uses the Heal ability on an ally or himself, enemies nearby will be knocked back and take damage. 9109083Equip accessory 9109084Tyrant Talons 9109085Artillery Strike 9109086Call down a barrage from allied Imperial Guard artillery positions. 9109087Call down a barrage from allied Imperial Guard artillery positions. 9109088Click and target area 9109089Eliminate the attackers 9109090Charge 9109091Charge at targeted location, knocking over everything in the charge path. 9109092Click and target area 9109093Fire Prism Pilot 9109094Guardian 9109095Equip bolter 9109104Does not require reloading 9109105Cyclone Missile Barrage 9109106Fire a cluster of missiles to damage all targets in a large area. 9109107Click and target an area 9109108Heavy Flamer 9109109The Heavy Flamer is effective against infantry in cover or buildings. Grants the Cleansing Flame ability. 9109110Equip heavy flamer 9109111Flamer 9109112%1SQUAD% 9109113%1SQUAD% and %2SQUAD% 9109114%1SQUAD%, %2SQUAD% and %3SQUAD% 9109115%1SQUAD%, %2SQUAD%, %3SQUAD% and %4SQUAD% 9109134All infantry squads 9109135all squads 9109141Usable by the Force Commander 9109142Usable by Tarkus 9109143Usable by Cyrus 9109144Usable Avitus 9109145Usable by Thule 9109146Usable by Thaddeus 9109147Usable by the Force Commander and Tarkus 9109148Usable by the Force Commander and Avitus 9109149Usable by the Force Commander and Thaddeus 9109150Usable by the Force Commander, Tarkus, Avitus and Cyrus 9109151Usable by all infantry 9109152Usable by all squads 9109153Default weapon for the Force Commander 9109154Default weapon for Tarkus 9109155Default weapon for Avitus 9109158Merciless Strike 9109159Lash out at a specified target with an explosive short-ranged melee attack. 9109160Lash out at a specified target with an explosive short-ranged melee attack. 9109161Click and target location 9109166Ethereal Slash 9109167A devastating slam that deals damage in an area around the Warlock 9109168A devastating slam that deals damage in an area around the Warlock 9109171Slugga Boy 9109172Basic infantry of feral Orks. 9109173Feral Ork Boyz 9109174Feral Boyz 9109175Ork Mob 9109176Shoota Boy 9109177Sector Update 9109178Level 2 Hive 9109179Adrenal Glands 9109180Increases Warrior health and damage, also allowing them to destroy vehicles in melee. Nearby melee Tyranids receive health bonuses. 9109181Trigger biomorph 9109182Ethereal Slash 9109183Slash enemies from a distance. 9109185Fire Prism 9109186Eldar Tank 9109187Fire Prism 9109188Fire Prism 9109189Eldar Heavy Grav Tank 9109190Dual Shuriken Catapult 9109191Heal 9109192Heal a targeted squad. This ability improves as the Apothecary gains levels. 9109193Click and target ally 9109194Purification Vials 9109195Purification Rites 9109196Purification Vials 9109197Purification Vials 9109198Purification Vials 9109200Holy Vigor 9109201With increased vigor, Thule s abilities can be used more often. 9109202With increased vigor, Thule s abilities can be used more often. 9109203Battle Lust 9109204Thule regains Energy for every enemy he kills. 9109205Thule regains Energy for every enemy he kills. 9109207No records exist of the Blood Ravens’ own Primarch, a fact that drives their number to a ceaseless search for knowledge. With none to dedicate the chapter’s past history to, the Great Father blessed this Assault Cannon to all of those legendary forefathers of the Space Marines. 9109208Zeal of the Primarchs 9109209%1CHANCE%%% chance per hit of +%2DAMAGE% Damage to all nearby enemy %3ARMORTYPE% 9109210%1CHANCE%%% chance per hit of +%2DAMAGE% Damage per second to all nearby enemy %3ARMORTYPE% for %4TIME% seconds 9109211%1CHANCE%%% chance per hit of +%2DAMAGE% Damage to %3ARMORTYPE% 9109212%1CHANCE%%% chance per hit of +%2DAMAGE% Damage per second to %3ARMORTYPE% for %4TIME% seconds 9109213%1CHANCE%%% chance per hit of +%2DAMAGE% Damage to all nearby %3RACE% %4ARMORTYPE% 9109214%1CHANCE%%% chance per hit of +%2DAMAGE% Damage per second to all nearby %3RACE% %4ARMORTYPE% for %5TIME% seconds 9109215%1CHANCE%%% chance per hit of +%2DAMAGE% Damage to %3RACE% %4ARMORTYPE% 9109216%1CHANCE%%% chance per hit of +%2DAMAGE% Damage per second to %3RACE% %4ARMORTYPE% for %5TIME% seconds 9109217+%1DAMAGE% Damage to all nearby enemy %2ARMORTYPE% 9109218+%1DAMAGE% Damage per second to all nearby enemy %2ARMORTYPE% for %3TIME% seconds 9109219+%1DAMAGE% Damage to %2ARMORTYPE% 9109220+%1DAMAGE% Damage per second to %2ARMORTYPE% for %3TIME% seconds 9109221+%1DAMAGE% Damage to all nearby %2RACE% %3ARMORTYPE% 9109222+%1DAMAGE% Damage per second to all nearby %2RACE% %3ARMORTYPE% for %4TIME% seconds 9109223+%1DAMAGE% Damage to %2RACE% %3ARMORTYPE% 9109224+%1DAMAGE% Damage per second to %2RACE% %3ARMORTYPE% for %4TIME% seconds 9109225buildings 9109226defensive buildings 9109227light buildings 9109228commanders 9109229heavy infantry 9109230infantry 9109231vehicles 9109232Techpriests on Typhon 9109233Techpriests have located a powerful Astronomic Array on Planet Typhon. This array can identify a weakness in the Tyranid Hive Fleet. 9109234Flesh Hook 9109235Power Sword - Ranger 9109238Not Used 9109249To Defeat the Hive 9109250You have a three part plan to defeat the Tyranids. You must find a weakness in the Hive Fleet, develop a poison to use against it, and secure the facilities to build the resulting weapons. 9109251Orks Attack Techpriests 9109252The Ork Gorwazza and his band are headed straight for the Techpriest base camp on Mt. Siccaris. If the Techpriests are killed, you may never locate the Astronomic Array. 9109253Orks Seek Array 9109254An Ork named Rippa-Splitta has stolen the dataslate with the location of the Astronomic Array and vanished into the jungle. Seek out his lieutenants to find the Array. 9109255Locate Rippa-Splitta or his lieutenants 9109256You have located Blitzzagga, an Ork Mek and lieutenant of Rippa-Splitta. He is your only lead in the search for the astronomic array and finding a weakness in the Hive Fleet. 9109257Confront Blitzzagga 9109258Mek Blitzzagga revealed that Rippa-Splitta s chief lieutenant is an Ork named Deff Driva. He is now your lead in the search for the astronomic array and finding a weakness in the Hive Fleet. 9109259Locate and confront Deff Driva 9109260Rippa-Splitta Located 9109261Thanks to your battle against Deff Driva, you have located the Ork Rippa-Splitta in Green Tooth Gorge on Typhon. He has the location of the astronomic array you must secure. 9109262Astronomic Array Located 9109263You finally have the location of the astronomic array. You must obtain the data from this array to find a weakness in the hive fleet. 9109264Hive Weakness Located 9109265The data you recovered from the astronomic array has allowed you to locate massive Tyranid ship controlling the Hive Fleet. You are a major step closer to victory. 9109266Primary Hive 9109267To develop a weapon to poison the Hive Fleet, you must obtain a bio-toxin sample from a primary Tyranid hive. To locate such a hive, you must obtain samples from key Tyranid creatures. 9109268Defeat Tyranids marked as "Prime Gene Samples" 9109269You have obtained an important Tyranid gene sample. Continue targeting prime gene samples to locate a primary hive. 9109270Defeat Tyranids marked as "Prime Gene Samples" 9109271Hive Located 9109272You have located a primary Tyranid hive in the depths of Typhon s Ladon Swamplands. A bio-toxin sample taken from it will allow you to create a weapon to attack the hive fleet. 9109273Complete "Into the Hive." 9109274Bio-Toxin Obtained 9109275You have obtained the necessary bio-toxin sample from the Tyranid Hive. You can now develop a weapon with which to strike at the Hive Fleet. You are a major step closer to victory. 9109276Eldar Plans 9109277Eldar have now been reported across the sub-sector. They may be continuing their plan with the Orks on Calderis and Typhon, but are also active on Meridian. Break their activities on the recruiting worlds once and for all. 9109278Uncover the Eldar plan 9109279Angel Forge 9109280In order to produce the weapons needed to defeat the Tyranid invasion, you must secure Angel Forge, a massive factory complex on Planet Meridian. 9109281Meridian is the capital of the sub-sector and home to billions of Imperial citizens. Travel there to obtain access to Angel Forge, where you can manufacture the weapon to defeat the Tyranids. 9109282The Eldar have launched a series of raids across Meridian. Assist the local forces in stopping them in order to obtain access to Angel Forge. 9109283Idranel 9109284The Warlock Aurian referred to another Eldar named Idranel. He or she may be the leader of Eldar activities in the sub-sector. Chapter Librarians are searching for data on this alien. 9109285Eldar and Angel Forge 9109286You have uncovered evidence that the Eldar are targeting Angel Forge on Meridian. The reasons why are unclear, but this threatens your plan to produce weapons against the Tyranids. 9109287Idranel of Ulthwe 9109288Chapter records have identified Idranel as a powerful Eldar Farseer. She is the leader of their activities in the sub-sector and must be eliminated. 9109289Locate Farseer Idranel 9109290All Quiet on Meridian 9109291Eldar raids on Meridian have ceased and your scans detect no Tyranid presence there. The sector governor is refusing to grant you speedy access to Angel Forge, however. 9109292Eldar Trickery 9109293The Eldar somehow deceived Meridian s sensors and masked the Tyranids approach. You have countered their tricks, but the Tyranids are now invading the planet in full force. 9109294Secure assets on Meridian. 9109295Defeat the Tyranid invaders. 9109296Idranel Located 9109297Farseer Idranel has been located on Meridian. She is the Eldar leader in the sector and must be defeated before she can threaten Angel Forge and the rest of Meridian. 9109298Idranel Escapes 9109299Farseer Idranel has escaped her fate, warping away just before you were to deliver the killing blow. She will surely return. 9109300Angel Forge Under Attack 9109301A mighty Tyranid swarm is headed straight for Angel Forge. The massive defensive gate protecting the forge has somehow opened and Ork raiders are also attacking. Only you can save Angel Forge. 9109302Ork Looters 9109303You have closed Angel Gate, but Orks are moving to raid valuable stores nearby. They must be stopped or they will put the Forge at risk again. 9109304Angel Forge Secure 9109305With Idranel defeated and Governor Vandis deposed, you have secured access to Angel Forge. There, you can manufacture the weapons needed to strike at the Tyranid Hive Fleet. You are a major step closer to victory. 9109306Chapter Fleet Approaching 9109307Gabriel Angelos and the Blood Ravens Fleet are mere days away from the sub-sector, where they can use the data and weapons you have obtained to attack the Hive Fleet. You must hold the sector until they arrive. 9109308Secure assets across the sector 9109309Hold out until the fleet arrives. 9109310The Warboss 9109311You have located Warboss Bonesmasha, the mighty Ork who has led the Greenskin invasion of Calderis and Typhon. Strike at him to end that threat once and for all. 9109312Complete "Raid Against the Warboss" 9109313The Avatar of Khaine 9109314The mad Eldar have summoned the daemonic Avatar on Typhon. This fiery incarnation of an alien God is their ultimate weapon. 9109315Complete "The Wailing Doom" 9109316Chapter Fleet Lost 9109317The Hive Mind has blocked Gabriel Angelos and his fleet from emerging from the Warp. This is a great blow to the Blood Ravens, but has forced the Hive Fleet into a vulnerable position. 9109318You have one chance to deliver a killing blow to the central Hive Ship while it feeds on Typhon. You will strike at the base of the great capillary tower it feeds from and deliver the poison manufactured at Angel Forge. Imperial Guard veterans from Meridian will provide support, but this is the ultimate battle. 9109319Complete "The Last Stand" 9109320Calderis Update 9109321Typhon Update 9109322Meridian Update 9109325Holo-field 9109326Camouflages units in an area for a period of time. 9109327Click and target area 9109329Click and target enemy vehicle 9109330And They Shall Know No Fear 9109331Temporarily receive less damage, knockback enemy melee units and gain suppression immunity, but move more slowly. (Damage to the squad charges this ability.) 9109332Click to activate 9109334Kustom Shoota 9109337Click to activate 9109346Ork Invasion 9109347Calderis is currently facing a massive Ork invasion that threatens to spill over to the entire sector. 9109348Stop the Ork Invasion 9109349Captain Thule needs you to travel to Typhon to stop the Eldar from stirring up another Ork Invasion. 9109350Eliminate all insurgents 9109351Captain Thule needs you to return to Calderis to help protect the capital from a major Ork offensive. 9109352Protect the Capital 9109353Tyranid Invasion 9109354A massive Tyranid hive fleet is descending on the sector. All life will be lost if your strike force doesn t find a way to stop them. 9109355Secure supply lines on Typhon 9109356Wait for Chapter Command to respond 9109357Captain Thule Poisoned 9109358Captain Thule was grievously wounded in the fight with the Tyranid Warrior. The deadly venom from the Warrior has caused him to slip into a coma. 9109359Locate the Warrior 9109360Press the Advantage 9109361Your initial assault has the Orks scattered and backpedaling. Use this opportunity to press into their flank and secure a vital supply route. 9109362Hidden Enemy 9109363Someone appears to be stirring up the Orks and pointing them at vital targets. Finding this hidden enemy is the key to stopping the Ork invasion once and for all. 9109364Eliminate Skykilla and Gutrencha 9109365Search for clues 9109366Eldar Presence 9109367The Eldar are stirring up the Orks in the sector, and trying to stir up a massive Waaaghh! Why they are doing this is a mystery, but Captain Thule fears the worst. 9109368Capital Under Siege 9109369The Orks are attacking the capital on Calderis. The entire planet will fall if you do not stop them. 9109370Hold the gate 9109371Thule s Attacker Located 9109372The Warrior that wounded Davian Thule has been located. Locate it, and destroy it to get a venom sample that may bring Captain Thule out of his coma. 9109373Eldar Inciting the Orks 9109374The Eldar are inciting the Orks on Typhon as well. Captain Thule needs you to travel to Typhon and terminate their agent on Typhon. 9109375Ork Invasion Stirring 9109376The Orks on Typhon are starting to rally around an assassin known as Bakstabba. This Ork leader must be eliminated before he can rally more Orks to his cause. 9109377Supply Lines Jeopardized 9109378An Eldar Ranger is leading raiding parties that are endangering supply lines on Typhon. Eliminate him with extreme prejudice. 9109381Click to activate 9109395Toggle On/Off 9109405Toggle On/Off 9109406Level 2 Hive 9109413Witchblade 9109414Level 2 Teleporta Platform 9109416Secure Those Strategic Assets 9109417Most regions contain special strategic assets which you can secure to gain valuable benefits. This includes unique wargear and abilities, bonuses when completing missions, and extra mission intelligence. 9109418There are three types of these assets Communication Arrays, Automated Foundries, and Imperial Shrines. 9109419When you secure a strategic assets, the Strike Cruiser deploys generators to power them. These generators remain on the ground after you leave and keep the asset secured. 9109420The Strike Cruiser can only provide one set of generators per deployment, however. To secure more, you need to return to the map on a later deployment. 9109421The enemy may launch an attack on your secured assets, prompting a distress signal for a Defense Mission. Complete these missions before they expire to ensure you do not lose the assets and the benefits it provides. 9109422Strategic Assets = Killer Wargear 9109423The Rosarius, Locator Beacon, and Signum are wargear items granted the first time you secure an Imperial Shrine, Automated Foundry, or Communication Array, respectively. 9109424Each item grants a powerful ability, but they all have limited uses per deployment. Capture more of the corresponding strategic asset on the planet you are orbiting to have more uses when launching a mission. 9109425For example, the Signum grants the Artillery Strike ability. Capturing Communication Arrays on Calderis will boost the number of artillery strikes you can use when on Calderis. 9109426Communication Arrays grant you many benefits 9109427They grant you the Signum, an item that allows you to call in disruptive Artillery Strikes. The more secured Arrays on a planet, the more uses per deployment. 9109428They provide bonus intelligence, such as enemy weaknesses. This intel appears on mission briefings if you control Arrays on that planet. 9109429They provide additional ordnance during Defense mission. The more Arrays you have secured across the sector, the more special abilities you will have during Defense missions. 9109430Imperial Shrines grant you many benefits 9109431They grant you the Rosarius, an item that allows you to make all your squads temporarily invincible. The more secured Shrines on a planet, the more uses per deployment. 9109432They slow the rate at which aliens are able to infest that planet, allowing you to better defend the sector. 9109433If you secure enough Shrines across all planets, you receive bonus experience upon completing each mission. 9109434Automated Foundries grant you many benefits 9109435They grant you the Locator Beacon, an item that allows you to deploy turrets during missions. The more secured Foundries on a planet, the more uses per deployment. 9109436They contribute to your chance to earn additional deployments in a solar day -- a bonus appears on the debrief screen at the end of a successful mission. 9109437If you secure enough Foundries across all planets, the requirements for earning extra deployments is reduced for all missions. 9109438Communication arrays are ancient relics that can broadcast signals across an entire continent. Capturing a communication array provides several benefits that will help you in the campaign. To secure the array, select a squad and right click on the array. 9109439Generators 9109440You have deployed generators around the communication array you just secured. These generators power the array and keep it under your control. You can only deploy generators once per mission, so you won t be able to secure additional strategic objectives until your next mission. 9109441You have acquired a Signum. A Signum allows you to call in artillery strikes from nearby Imperial Guard batteries. Capturing additional arrays on this planet will allow you to call in additional strikes per mission when on this planet. You can equip the Signum when you return to the strike cruiser. 9109442Additional Benefits 9109443Communication arrays provide you with additional intel in mission briefings. The more arrays you control, the more intel you will receive. Controlling numerous arrays across all planets also increases available ordnance during defend missions. 9109444Imperial shrines are temples dedicated to the Emperor of Man. They channel the powerful psychic energies that are generated by the devotion of Imperial citizens. Capturing a shrine will offer many benefits over the course of the campaign. To secure the shrine, select a squad and right click on the shrine. 9109445You have deployed generators around the shrine you just secured. These generators power the shrine and keep it under your control. You can only deploy generators once per mission, so you won t be able to secure additional strategic objectives until your next mission. 9109446You have acquired a Rosarius. The Rosarius is a holy relic and offers temporary invulnerability. Capturing additional shrines on this planet will allow you to use the Rosarius more than once per mission on this planet. You can equip the Rosarius when you return to the strike cruiser. 9109447Imperial shrines provide you with multiple benefits. Shrines reduce the rate that enemies can invade the planet, and reduce the effects of their invasion. Controlling several shrines also provides an experience bonus at the end of each mission. 9109448Automated foundries are prized relics from the past that are capable of mass production on a scale that dwarfs current technology. Capturing a foundry provides several benefits that will help you in the campaign. To secure the foundry, select a squad and right click on the foundry. 9109449You have deployed generators around the foundry you just secured. These generators power the foundry and keep it under your control. You can only deploy generators once per mission, so you won t be able to secure additional objectives until your next mission. 9109450You have acquired a Locator Beacon. Locator Beacons allow you to call down automated turrets. Capturing additional foundries on this planet will allow you use the Locator Beacon additional times in a mission on this planet. You can equip the Locator Beacon when you return to the strike cruiser. 9109451Automated foundries provide you with a bonus at the end of each mission that makes it easier to gain additional deployments in the same solar day. Multiple deployments in a solar day are your best chance of staying ahead of the enemy, and pushing back the invasion. Controlling multiple foundries will also lower the requirements for multiple deployments. 9109452The array you ve secured is under attack by the enemy. You need to protect the generators that power the array and hold out until the enemy s attack is exhausted. 9109453The shrine you ve secured is under attack by the enemy. You need to protect the generators that power the shrine and hold out until the enemy s attack is exhausted. 9109454The foundry you ve secured is under attack by the enemy. You need to protect the generators that power the foundry and hold out until the enemy s attack is exhausted. 9109455Defense Ordnance 9109456You have access to different types of ordnance for defend missions. How many types of ordnance you have depends on the number of Communications Arrays you control. You always have access to automated turrets. Additional arrays will unlock new ordnance types. 9109457Gabriel Angelos 9109458Right-click to have infantry enter this structure. 9109459Right-click to have infantry enter this structure. 9109460Right-click to have infantry enter this structure. 9109461Right-click to have infantry enter this structure. 9109462Right-click to have infantry enter this structure. 9109463Right-click to have infantry enter this structure. 9109464Ork Structure 9109465Ork Structure 9109466Ork Structure 9109467Ork Guard Tower 9109468Ork Structure 9109469Ork Guard Tower 9109470Choppa 9109471Tyranid Invisible Warrior 9109472 9109473 9109474Force Commander 9109475Terminator Squad 9109476Infantry 9109477Infantry 9109478Foundry Bonus 9109479Each Automated Foundry secured on this planet adds to your overall mission performance. 9109480Bonus Deployment 9109481Achieve this mission performance to be awarded an extra deployment for this campaign day. 9109484Astronomic Array 9109485Power Generator 9109486Secures the nearby strategic asset 9109487Blood Ravens 9109488Blood Ravens Chapter 9109489Dark Angels 9109490Dark Angels Chapter 9109491White Scars 9109492White Scars Chapter 9109493Space Wolves 9109494Space Wolves Chapter 9109495Imperial Fists 9109496Imperial Fists Chapter 9109497Blood Angels 9109498Blood Angels Chapter 9109499Iron Hands 9109500Iron Hands Chapter 9109501Ultramarines 9109502Ultramarines Chapter 9109503Salamanders 9109504Salamanders Chapter 9109505Raven Guard 9109506Raven Guard Chapter 9109507Black Templars 9109508Black Templars Chapter 9109509Bad Moonz Clan 9109510Bad Moonz 9109511Death Skulls Clan 9109512Death Skulls 9109513Evil Sunz Clan 9109514Evil Sunz 9109515Goffs Clan 9109516Goffs 9109517Blood Axes Clan 9109518Blood Axes 9109519Snake Bites Clan 9109520Snake Bites 9109521Goldtoofs Warband 9109522Goldtoofs 9109523Bigchoppaz Warband 9109524Bigchoppaz 9109525Speed Freak Kult 9109526Speed Freaks 9109528Ulthwe 9109529Craftworld Ulthwe 9109530Iyanden 9109531Craftworld Iyanden 9109532Alaitoc 9109533Craftworld Alaitoc 9109534Biel-Tan 9109535Craftworld Biel-Tan 9109536Saim-Hann 9109537Craftworld Saim-Hann 9109538Yme-Loc 9109539Craftworld Yme-Loc 9109540Altansar 9109541Craftworld Altansar 9109542Lugganath 9109543Craftworld Lugganath 9109544Il-Kaithe 9109545Craftworld Il-Kaithe 9109546Iybraesil 9109547Craftworld Iybraesil 9109548Leviathan 9109549Hive Fleet Leviathan 9109550Leviathan Variant 9109551Hive Fleet Leviathan Variant 9109552Leviathan Variant 2 9109553Hive Fleet Leviathan Variant 2 9109554Kraken 9109555Hive Fleet Kraken 9109556Behemoth 9109557Hive Fleet Behemoth 9109559Kaelor 9109560Craftworld Kaelor 9109561Flesh Tearers 9109562Flesh Tearers Chapter 9109563Blood Angels Death Company 9109564Dark Angels Deathwing 9109565Crimson Fists 9109566Crimson Fists Chapter 9109567Silver Skulls 9109568Silver Skulls Chapter 9109569Colossus 9109570Hive Fleet Colossus 9109571Hydra 9109572Hive Fleet Hydra 9109573Jormungandr 9109574Hive Fleet Jormungandr 9109575Tiamet 9109576Hive Fleet Tiamet 9109577Ophidia 9109578Hive Fleet Ophidia 9109579Ouroboris 9109580Hive Fleet Ouroboris 9109581Kraken Splinter Fleet 9109582Leviathan Splinter Fleet 9109583Behemoth Splinter Fleet 9109584Harbinger 9109585Apophis 9109586Dagon 9109587Perseus 9109588Locust 9109589Scarabus 9109590Hive Fleet Harbinger 9109591Hive Fleet Apophis 9109592Hive Fleet Dagon 9109593Hive Fleet Perseus 9109594Hive Fleet Locust 9109595Hive Fleet Scarabus 9109596Behemoth - Prandium Tendril 9109597Behemoth - Macragge Tendril 9109598Behemoth - Tyran Tendril 9109599Behemoth - Thadros Tendril 9109600Behemoth - Phall Tendril 9109601Behemoth - Valos Tendril 9109602Kraken - Ichar Tendril 9109603Kraken - Devlan Tendril 9109604Kraken - Darson Tendril 9109605Kraken - Graia Tendril 9109606Kraken - Lamarno Tendril 9109607Kraken - Miral Tendril 9109608Kraken - Moloch Tendril 9109609Kraken - Kreel Tendril 9109610Kraken - Sotha Tendril 9109611Kraken - Veridian Tendril 9109612Leviathan - Octavius Tendril 9109613Leviathan - Gryphonne Tendril 9109614Leviathan - Tarsis Tendril 9109615Leviathan - Valedor Tendril 9109616Leviathan - Capilene Tendril 9109617Leviathan - Tesla Tendril 9109618Leviathan - Carpathia Tendril 9109621Hotkey %1HOTKEY% 9109622Warp Field 9109623Activate a protective shield. 9109624Click and target ally 9109629Move Avitus near the beacon 9109630Angels of Absolution 9109631Angels of Absolution Chapter 9109632Angels of Redemption 9109633Angels of Redemption Chapter 9109634Angels of Vengence 9109635Angels of Vengence Chapter 9109636Marauders 9109637Marauders Chapter 9109638Rampagers 9109639Rampagers Chapter 9109640Storm Lords 9109641Storm Lords Chapter 9109642Angels Encarmine 9109643Angels Encarmine Chapter 9109644Angels Sanguine 9109645Angels Sanguine Chapter 9109646Angels Vermillion 9109647Angels Vermillion Chapter 9109648Blood Drinkers 9109649Blood Drinkers Chapter 9109650Red Talons 9109651Red Talons Chapter 9109652Brazen Claws 9109653Brazen Claws Chapter 9109654Novamarines 9109655Novamarines Chapter 9109656White Consuls 9109657White Consuls Chapter 9109658Black Consuls 9109659Black Consuls Chapter 9109660Preators of Orpheus 9109661Preators of Orpheus Chapter 9109662Genesis 9109663Genesis Chapter 9109664Revilers 9109665Revilers Chapter 9109666Raptors 9109667Raptors Chapter 9109668Ravener Tunnel 9109669Tyranid Tunnel that allows infantry to travel through. 9109670Ravener Tunnel 9109671Building 9109672Move at increased speed for a brief period. 9109673"Never forget the sacrifices your brothers have made. Their blood is your blood." From the sermons of Chaplain Mikelus 9109674MkIIIb Terminator Issue. Integrated into Terminator armor, this mighty power fist delivers devastating strikes against the enemies of man. Effective against infantry and armor alike. 9109679You have gained a new rank! 9109680You have earned a new rank! 9109681You have reached the next army level! 9109682Your %1RACE% army level is now 9109683Your %1RACE% army level is now 9109684Your %1RACE% army level is now 9109685Your %1RACE% army level is now 9109686Your %1RACE% army level is now 9109687Your %1HERO% is now 9109688Rank %1RANK_NUM% %2RANK_NAME% 9109689Your %1SQUADS% army now equips 9109690Your %1SQUADS% now equip 9109691%1WARGEAR% 9109693Witchblade 9109695Runes of Reaping 9109696Capillary Tower 9109697Capillary Tower 9109698Capillary Tower 9109700Blood Runes 9109702Runes of Reaping 9109705Grants the Rally ability 9109707Can hit multiple targets 9109708Thrown Weapon 9109709Thrown Weapon 9109710Thrown Weapon 9109711Limited Use 9109712Limited Use 9109713Limited Use 9109714Limited Use 9109715Heals all nearby allies 9109716Limited Use 9109717Limited Use 9109718Thrown Weapon 9109719Laurels of Command 9109720Allows reinforcements to arrive via drop pod. In addition to replacing fallen squad members, a drop pod can be a powerful weapon in and of itself, crushing those caught beneath it. 9109721Damages targets at impact point 9109722Thrown Weapon 9109723Can hit multiple targets 9109728Merciless Strike 9109729Lash out at a specified target with an explosive short-ranged melee attack. 9109730Lash out at a specified target with an explosive short-ranged melee attack. 9109731Click and target location 9109732Assault Jump 9109733Soar over the battlefield, landing with a powerful impact that disrupts and damages enemy units. 9109734Soar over the battlefield, landing with a powerful impact that disrupts and damages enemy units. 9109735Click and target area 9109736Cyclone Missile Launcher 9109737Auxiliary Weapon 9109738+1 to Ranged Combat Discipline 9109739These weapons, fitted to the ancient and mighty suits of Tactical Dreadnought Armor, are essentially large racks of missiles enabling the Terminator Marine to engage vehicular and infantry targets. 9109742To save your progress in Dawn of War II, you must create a profile. 9109744Create a profile now 9109749--RICH PRESENCE XLAST 9109750-- Campaign 9109751{(C)PRES_CTX_CAMPAIGN_NAME}, Level {(P)PRES_PROP_CAMPAIGN_LEVEL} 9109752Day {(P)PRES_PROP_DAY_NUMBER} - {(C)PRES_CTX_CAMPAIGN_STATUS} 9109753-- Idle 9109754Idle 9109755-- Main Menu 9109756Main Menu 9109757--Ranked Game 9109758Ranked Game 9109760Skirmish Game 9109761Multiplayer Game 9109762{(C)PRES_CTX_VICTORY_CONDITION} - {(C)PRES_CTX_MAP_NAME} 9109763CTXS_CAMPAIGN_ELDAR- Eldar 9109764CTXS_CAMPAIGN_ORK - Ork 9109765CTXS_CAMPAIGN_SPACE_MARINE - Space Marine 9109766CTXS_CAMPAIGN_STATUS_FIGHTING_ELDAR - Fighting Eldar 9109767CTXS_CAMPAIGN_STATUS_FIGHTING_ORKS - Fighting Orks 9109768CTXS_CAMPAIGN_STATUS_SPACE_MARINES - Fighting Space Marines 9109769CTXS_CAMPAIGN_STATUS_FIGHTING_TYRANIDS - Fighting Tyranids 9109770CTXS_CAMPAIGN_STATUS_MERIDIAN - Orbitting Meridian 9109771CTXS_CAMPAIGN_STATUS_TYPHON - Orbitting Typhon 9109772CTXS_CAMPAIGN_TYRANID - Tyranid 9109773CTXS_CAMPGAIN_STATUS_CALDERIS - Orbitting Calderis 9109774CTXS_CAMPGAIN_STATUS_CALDERIS - Victory Point 9109775(2p) Siwal Frontier 9109776(2p) Legis High Stratum 9109777(2p) Green Tooth Jungle 9109778(6p) Capital Spire 9109779This will permanently delete this replay file. Are you sure you want to proceed? 9109780Choose your language 9109783No Multiplayer Privilege 9109784Multiplayer privileges have been disabled on your account. 9109785Level 2 Webway Assembly 9109786Army Level 9109787Army Experience Required %1EXPERIENCE_REQUIRED% 9109788Army Level %1LEVEL% 9109789Army Level %1LEVEL% - %2CLASS% 9109790Next Army Level 9109791%1EXP% RP 9109794Fires a burst of concentrated psy energy at a target 9109795igguy 9109798Kustom Shoota 9109799Notice 9109800Connection to authentication server has been lost. Please ensure the Steam client is running. 9109801Notice 9109802You must be connected to the authentication server to play multiplayer. Please ensure the Steam client is running in online mode. 9109803Deploy Tarantula 9109804Deploy a Tarantula sentry gun at the designated location. Heavy bolter turret damages and suppresses enemy infantry. 9109805Deploy a Tarantula sentry gun at the designated location. Heavy bolter turret damages and suppresses enemy infantry. 9109806Click and target location 9109807Tankbusta Bomb 9109808Throw a bomb that sticks to wagons. Damages and disables vehicles. 9109809Throw stickybomb to damage and disable a vehicle 9109810Click and target enemy vehicle 9109811Scout Marine 9109813Armor 9109814Mk VII Aquila type. Made from thick ceramite plates and laced with electrically motivated fiber bundles, this heavy armor is distinctive of Space Marines. 9109820Power Armor 9109821You require more Requisition 9109822You require more Power 9109823You require more Energy 9109824Population Capacity Reached 9109825You require more Waaagh! Stomp and kill! 9109826You require more Zeal. Exterminate your enemies! 9109827You require more Psychic Might. Kill your enemies. 9109828You require more Biomass. Attack your enemies. 9109829A version of Dawn of War II is currently running. You must close all open instances of Dawn of War II before you can begin the install. 9109830An error occurred while configuring essential DirectX components. The install cannot continue. Please contact THQ technical support. 9109831Play Dawn of War II 9109832Read compatibility notes, game tips, and release notes for Dawn of War II 9109833Play 9109834Home Page 9109835http //www.dawnofwar2.com 9109836Support 9109837http //support.thq.com/ 9109838Register 9109839http //www.dawnofwar2.com/register 9109840View Readme 9109841Create and edit skirmish, multiplayer, and single-player maps 9109842Configuring DirectX 9109843Creating the installation directory 9109844Configuring uninstall information 9109846Installing the Microsoft C/C++ runtime 9109847Installing files 9109848Installing supplementary documentation 9109849Configuring the Media Center launcher 9109850Configuring the Start menu 9109851Configuring the Windows Firewall 9109852Configuring the Games Explorer 9109853Installation complete 9109854Configuring Rich Save Game support 9109855Uninstall Dawn of War II
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NEW REM NAME COPY PREV NEXT EDIT INITIAL CONDITION CLASS MECHANICAL THERMAL JOULE MAGNETOSTATIC FLUID DIFFUSION STATE VARIABLES GENERAL DRAW INITIAL CONDS ON MESH ID INITIAL CONDS ARROW PROT SETTINGS MERGE DUPLICATE INITIAL CONDS REMOVE ALL INITIAL CONDS
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A Pinch to Grow an Inch Scorpion,Giant / T1 The Blighted Isle DarkElfスタート地点から坂を上がった町(5k,11k)にいるNPC Nehmora the Hagが持っているクエストを消化する。 確かFallen Kin>Lucrative Intrigue。Lucrativeが出なかったらDance of Khaineも。 Fast Finds Spider,Giant / T1 Nordland Chapter4の町でKill Collecter Taskを上限まで(およそ60)こなす。ターゲットはSpider。 町から南に3箇所ほど群生ポイントあり。 カウントはTomeBook左タブBestialy>Incect>Spider,Giantの数字を見れば楽。 Avoid a Gory End Boar / T1 MountBloodhorn Chapter2の町でKill Collecter Taskを上限までこなす。ターゲットはDog xxxというHuman Bandit。 町のNのPQAreaに大量にいる。 Slops o the Day Vulture / T1 Mount Bloodhorn Chapter3の町の小屋の中にいるBloody Sun Burnerと話してSack of Rotting Fruitを貰う。 Healerのいる場所からNの小屋。 その後22k,24kあたりへ行き、幾つか落ちているSlop BasketをSackが空になるまでクリックして回る。 終わったらBurnerの元へ戻り、話せばUnlock。 Things With Wings Bat,Giant / T2 Ostland 21.5K,29K or 31k,46k or 39k,40kのどれかに居るHeartraker(Lv17Champion Bat)を倒す。 Groupでやる場合Killblowの人だけUnlockになるかもしれない。 Deadly When Dead Scorpion,Giant / T2 The Shadowlands 2k,41.5kあたりにいるNormal Scorpionを倒しているとUnlock。 多分自動lootItem→Unlockと同時にItem処分かな。100%ではないので数体倒すと良い。 Champもいるが無関係。 Finger Licking Good Ghoul / T4 Cinderfall Chapter18の町でKill Collecter Taskを上限までこなす。多分60体。 ターゲットは54k,43kの墓地にいるGhoul。 Heading for Profit Bear / T4 Praag 62k,30kの洞窟内部にいる熊を倒し、Deadmaul s Pawを拾う。これをMerchantに売ればUnlock。 Picky Eater Hound / T4 Praag Chapter 19の町にいるRaven War Sapper(犬を連れたガード)と話し、空のバッグを貰う。 その後、町の傍にいる馬をバッグがフルになるまで倒し、ガードと話す。 Well Watched Weaklings Warhawk / T4 Praag 58k,50kの山の上にいるSnowperch Matriarch(Lv37Hero)を倒す。 居ない場合は、そこにいるSnowperch Fledglings(lv36Normal)を倒せば沸く。 このlocまで上がるのが大変だった。 62.5k,60kあたりの岩からNへジャンプ。画像1 その後NWへ進み、岩の上から木の根元へジャンプして山を登る。画像2 Not So Great Any More Great Cat / T4 Reikland 2k,18KでGrinyaを倒すor59k,19kでBloodmaneを倒す。両方Rank38Normal。 Hunger Pangs Giant Lizard / T4 Kadrin Valley Chapter 21の町のKillCollecter Taskを上限までこなす。ターゲットはトカゲ。 西に出てすぐと道を挟んでさらに西の奥に群生ポイントあり。 KnockDownが非常にだるい。 Sharpen Your Knives Bear / T4 Kadrin Valley 5k,14.6kにいるThag Bolger(Lv32 Normal)を倒す。 名前 コメント
https://w.atwiki.jp/mrfrtech/pages/27.html
Market Scenario The elements responsible for developing the railroad stage security market include the rising need to limit the danger of unapproved admittance to stages and expanding interest for extra help and progressed answers for security the executives. Railroad traveler security is interlinked with the wellbeing and security of rail line resources like rail line stages and trains. Limiting unapproved access with the assistance of control frameworks guarantees an undeniable degree of safety for travelers as well as products at the rail route stage. Global Railway Platform Security Market is expected to register a CAGR of 5.5% during the review period, 2019–2025. A few measures are taken to limit unapproved access through fencing for railroad tracks, the establishment of CCTVs at high-hazard areas, the arrangement of data to chance gatherings, and the increase of oversight. Access control frameworks assume an essential part in forestalling unapproved access via the robotizing passage and leave activities and getting significant regions. In addition, the section of unapproved people and an enormous number of guests lead to unmanageable groups on railroad stages with the presence of automated multi-passage and leave focuses at stations that can be powerless against security dangers; subsequently, the need to limit the danger of unapproved admittance to stages has expanded. The worldwide railroad stage security market has been sectioned based on the part, application, and locale. Under the part section arrangements, sub-fragment is ascribed to holding potential development possibilities though, among the administrations sub-portion, oversaw administrations are relied upon to develop fundamentally during the figure time frame. Request a Free Sample @ https //www.marketresearchfuture.com/sample_request/8742 Competitive Outlook The Global Railway Platform Security Market is characterized by the presence of several regional and local providers. Some of the key players in the market are Honeywell (US), Indra Sistemas (Spain), Huawei (China), Bosch (Germany), Atos (France), FLIR Systems (US), Axis Communications (Sweden), talent (UK), Zhejiang Dahua (US), Hikvision (China), STANLEY (US), Wabtec (US), L T Technology Services (India), Mitsubishi Electric (Japan), Genetec (Canada), Knorr-Bremse (Germany), Nabtesco (Japan), Senstar (Canada), Avnet (US), and Anixter (US) among others. Segmentation The Global Railway Platform Security Market has been divided in view of parts, applications, and districts. By part, the market has been sectioned into arrangements and administrations. The arrangement section covers sensors, caution frameworks, and video observation frameworks. The different sorts of sensors remembered for the sensors fragment are microwave sensors, infrared sensors, fiber optic sensors, radar sensors, and different sensors. The video reconnaissance frameworks section has been additionally divided into programming and equipment. The equipment section incorporates cameras and capacity gadgets, while the product fragment incorporates astute video examination programming and video the board programming. By administrations, the market has been partitioned into proficient administrations and overseen administrations. By application, the market has been fragmented into metros and trains. The locales remembered for the review are North America, Europe, Asia-Pacific, the Middle East and Africa, and South America. Regional Analysis Geologically, Global Railway Platform Security Market has been arranged into four locales, in particular North America, Europe, Asia-Pacific, Middle East and Africa, and South America. North America is relied upon to overwhelm the worldwide railroad stage security market with the most noteworthy portion of the overall industry, though Asia-Pacific (APAC) is relied upon to be the quickest developing area in the rail line stage security market because of the expanding reception of trend-setting innovations and expanding GDP of Asia-Pacific nations. Additionally, likely economies in the Asia-Pacific area like China, Korea, Australia, Singapore, Hong Kong, and India are quickly putting resources into the innovative change as would be considered normal to fuel the development of the Global Railway Platform Security Market around here. Industry News September 2019 Honeywell sent off another product named Forge Cybersecurity Platform that improves, fortifies and scales online protection for resource concentrated organizations and basic foundation confronting digital dangers. The new programming securely moves information starting with one site then onto the next, utilizes tasks information to reinforce endpoint and organization security, and further develops online protection consistency. February 2019 Indra Sistemas joined forces with Begirale, an innovation-based organization that had practical experience in PC vision and PC insight. As per the association, Indra Sistemas would utilize Begirale s items, Begicrossing and Begirail, to further develop rail line wellbeing. November 2018 Hikvision refreshed the adaptations of its warm profound learning shot cameras, which offer different upgraded capacities for border security, alongside the high-level discharge recognition innovation. Table of Contents 1Executive Summary 2Scope of the Report 2.1Market Definition 2.2Scope of the Study 2.2.1Research objectives 2.2.2Assumptions Limitations 2.3Markets Structure Continued…. Browse Full Report Details @ https //www.marketresearchfuture.com/reports/railway-platform-security-market-8742 List of Tables Table 1 Global Railway Platform Security Market By Region, 2020-2027 Table 2 North America Railway Platform Security Market by Country, 2020-2027 Table 3 Europe Railway Platform Security Market By Country, 2020-2027 Continued… List of Figures FIGURE 1 Global Railway Platform Security Market Segmentation FIGURE 2 Forecast Methodology FIGURE 3 Five Forces Analysis of Global Railway Platform Security Market Continued… Similar Report Application Management Services Market By Service-Type (System Integration, Consulting Services, Modernization Services, And Others), By Organization Size, By Deployment, And By End-Users Open Source Intelligence (OSINT) Market By Security Type (Human Intelligence, Content Intelligence, Dark Web Analysis, Link/Network Analysis, Data Analytics, Text Analytics, Artificial Intelligence, Big Data, Others), Technology (Bid Data Software, Video Analytics, Text Analytics, Visualization Tool, Cyber Security, Web Analysis, Social Media Analysis, Others), Application (Military Defense, Homeland Security, Private Sector, Public Sector, National Security, Others) About Market Research Future Market Research Future (MRFR) has created a niche in the world of market research. It is counted among the top market research companies that offer well-researched and updated market research reports and insights to businesses of all sizes. What sets us apart is our super-responsive team that offers quality work keeping clients abridged of the prospective challenges and opportunities in various markets. Our team is adept in their space as well as patiently listens to every client. The best part is they know their work inside out and possess the expertise to guide the client in the right direction and achieve results on a tight deadline. We are a one-stop solution for all your data research needs. Our team does not believe in the “one size fits all” approach to creating a report that is detailed and concise. We handle 13 industry verticals including Healthcare, Chemicals and Materials, Information and Communications Technology, Semiconductor and Electronics, Energy and Power, Food, Beverages Nutrition, Automobile, Consumer and Retail, Aerospace and Defense, Industrial Automation and Equipment, Packaging Transport, Construction, and Agriculture. With our unique approach for every market report, we aim to reach the zenith in qualitative business intelligence and syndicated market research. Contact Market Research Future (Part of Wantstats Research and Media Private Limited) 99 Hudson Street, 5Th Floor New York, NY 10013 United States of America 1 628 258 0071 (US) 44 2035 002 764 (UK) Email sales@marketresearchfuture.com Website https //www.marketresearchfuture.com #market #research #industry #data #growth #trend #report #analyis #share #marketing #forecast #digital #geographic #demographic #gnews Plugin Error キーワードを入力してください。 #tech #researchreport #marketreport #futrue